Circulating microRNA miR-425-5p Associated with Brain White Matter Lesions and Inflammatory Processes
White matter lesions (WML) emerge as a consequence of vascular injuries in the brain. While they are commonly observed in aging, associations have been established with neurodegenerative and neurological disorders such as dementia or stroke. Despite substantial research efforts, biological mechanism...
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MDPI AG
2024-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/2/887 |
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| author | Sandra Van der Auwera Sabine Ameling Katharina Wittfeld Stefan Frenzel Robin Bülow Matthias Nauck Henry Völzke Uwe Völker Hans J. Grabe |
| author_facet | Sandra Van der Auwera Sabine Ameling Katharina Wittfeld Stefan Frenzel Robin Bülow Matthias Nauck Henry Völzke Uwe Völker Hans J. Grabe |
| author_sort | Sandra Van der Auwera |
| collection | DOAJ |
| description | White matter lesions (WML) emerge as a consequence of vascular injuries in the brain. While they are commonly observed in aging, associations have been established with neurodegenerative and neurological disorders such as dementia or stroke. Despite substantial research efforts, biological mechanisms are incomplete and biomarkers indicating WMLs are lacking. Utilizing data from the population-based <i>Study of Health in Pomerania</i> (SHIP), our objective was to identify plasma-circulating micro-RNAs (miRNAs) associated with WMLs, thus providing a foundation for a comprehensive biological model and further research. In linear regression models, direct association and moderating factors were analyzed. In 648 individuals, we identified <i>hsa</i>-miR-425-5p as directly associated with WMLs. In subsequent analyses, <i>hsa</i>-miR-425-5p was found to regulate various genes associated with WMLs with particular emphasis on the <i>SH3PXD2A</i> gene. Furthermore, miR-425-5p was found to be involved in immunological processes. In addition, noteworthy miRNAs associated with WMLs were identified, primarily moderated by the factors of sex or smoking status. All identified miRNAs exhibited a strong over-representation in neurodegenerative and neurological diseases. We introduced <i>hsa</i>-miR-425-5p as a promising candidate in WML research probably involved in immunological processes. Mir-425-5p holds the potential as a biomarker of WMLs, shedding light on potential mechanisms and pathways in vascular dementia. |
| first_indexed | 2024-03-08T09:54:24Z |
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| id | doaj.art-fc53b5c5f71a4d9492d52bb9d44ae8a0 |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T09:54:24Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fc53b5c5f71a4d9492d52bb9d44ae8a02024-01-29T13:55:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-01-0125288710.3390/ijms25020887Circulating microRNA miR-425-5p Associated with Brain White Matter Lesions and Inflammatory ProcessesSandra Van der Auwera0Sabine Ameling1Katharina Wittfeld2Stefan Frenzel3Robin Bülow4Matthias Nauck5Henry Völzke6Uwe Völker7Hans J. Grabe8Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, GermanyInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, GermanyDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, GermanyDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, GermanyInstitute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, 17475 Greifswald, GermanyGerman Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, 17475 Greifswald, GermanyGerman Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, 17475 Greifswald, GermanyInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, GermanyDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, GermanyWhite matter lesions (WML) emerge as a consequence of vascular injuries in the brain. While they are commonly observed in aging, associations have been established with neurodegenerative and neurological disorders such as dementia or stroke. Despite substantial research efforts, biological mechanisms are incomplete and biomarkers indicating WMLs are lacking. Utilizing data from the population-based <i>Study of Health in Pomerania</i> (SHIP), our objective was to identify plasma-circulating micro-RNAs (miRNAs) associated with WMLs, thus providing a foundation for a comprehensive biological model and further research. In linear regression models, direct association and moderating factors were analyzed. In 648 individuals, we identified <i>hsa</i>-miR-425-5p as directly associated with WMLs. In subsequent analyses, <i>hsa</i>-miR-425-5p was found to regulate various genes associated with WMLs with particular emphasis on the <i>SH3PXD2A</i> gene. Furthermore, miR-425-5p was found to be involved in immunological processes. In addition, noteworthy miRNAs associated with WMLs were identified, primarily moderated by the factors of sex or smoking status. All identified miRNAs exhibited a strong over-representation in neurodegenerative and neurological diseases. We introduced <i>hsa</i>-miR-425-5p as a promising candidate in WML research probably involved in immunological processes. Mir-425-5p holds the potential as a biomarker of WMLs, shedding light on potential mechanisms and pathways in vascular dementia.https://www.mdpi.com/1422-0067/25/2/887circulating miRNAsvascular dementiawhite matter lesionsinflammatory processesgeneral population<i>SH3PXD2A</i> |
| spellingShingle | Sandra Van der Auwera Sabine Ameling Katharina Wittfeld Stefan Frenzel Robin Bülow Matthias Nauck Henry Völzke Uwe Völker Hans J. Grabe Circulating microRNA miR-425-5p Associated with Brain White Matter Lesions and Inflammatory Processes International Journal of Molecular Sciences circulating miRNAs vascular dementia white matter lesions inflammatory processes general population <i>SH3PXD2A</i> |
| title | Circulating microRNA miR-425-5p Associated with Brain White Matter Lesions and Inflammatory Processes |
| title_full | Circulating microRNA miR-425-5p Associated with Brain White Matter Lesions and Inflammatory Processes |
| title_fullStr | Circulating microRNA miR-425-5p Associated with Brain White Matter Lesions and Inflammatory Processes |
| title_full_unstemmed | Circulating microRNA miR-425-5p Associated with Brain White Matter Lesions and Inflammatory Processes |
| title_short | Circulating microRNA miR-425-5p Associated with Brain White Matter Lesions and Inflammatory Processes |
| title_sort | circulating microrna mir 425 5p associated with brain white matter lesions and inflammatory processes |
| topic | circulating miRNAs vascular dementia white matter lesions inflammatory processes general population <i>SH3PXD2A</i> |
| url | https://www.mdpi.com/1422-0067/25/2/887 |
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