Juglone induces apoptosis of tumor stem-like cells through ROS-p38 pathway in glioblastoma

Juglone induces apoptosis of tumor stem-like cells through ROS-p38 pathway in glioblastoma

Abstract Background Juglone is a natural pigment, which has cytotoxic effect against various human tumor cells. However, its cytotoxicity to glioma cells, especially to tumor stem-like cells (TSCs) has not been demonstrated. Methods TSCs of glioma were enriched from U87 and two primary cells (SHG62,...

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Bibliographic Details
Main Authors: Jinfeng Wu, Haibo Zhang, Yang Xu, Jingwen Zhang, Wei Zhu, Yi Zhang, Liang Chen, Wei Hua, Ying Mao
Format: Article
Language:English
Published: BMC 2017-04-01
Series:BMC Neurology
Subjects:
Juglone
Glioma
Tumor stem-like cells
Apoptosis
Reactive oxygen species
Online Access:http://link.springer.com/article/10.1186/s12883-017-0843-0

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