Green microwave quantum dots as luminescent probes for quantifying prucalopride: consistency of content and application to pharmacokinetic studies
Abstract Prucalopride (PCP) is a medication used for the management of constipation via regulating bowel motions. PCP is widely used all over the world. So, novel, rapid, and highly sensitive carbon dots N-CQDs were obtained from Eruca Sativa juice via microwave approach in 4 min. The luminescence p...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-07-01
|
| Series: | BMC Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13065-023-01002-4 |
| _version_ | 1797774455441719296 |
|---|---|
| author | Baher I. Salman |
| author_facet | Baher I. Salman |
| author_sort | Baher I. Salman |
| collection | DOAJ |
| description | Abstract Prucalopride (PCP) is a medication used for the management of constipation via regulating bowel motions. PCP is widely used all over the world. So, novel, rapid, and highly sensitive carbon dots N-CQDs were obtained from Eruca Sativa juice via microwave approach in 4 min. The luminescence power of N-CQDs was declined by the increasing prucalopride concentration at emission 518 nm with linearity ranged from 3.00 to 200.00 ng mL−1. The luminescent antecedent was utilized for the test of PCP in human plasma with the rate of recovery extending from 95.06 to 98.40%. The new technique is an eco-friendly analytical method that can be easily applied in clinical laboratories. This assay is also simple, sensitive, and applied to therapeutic laboratories and subsequent pharmacokinetic studies in several clinical laboratories. Furthermore, the N-CQDs nano-sensor was able to distinguish the target drug from interferents commonly found in human plasma, indicating its high specificity and selectivity for PCP detection. |
| first_indexed | 2024-03-12T22:20:21Z |
| format | Article |
| id | doaj.art-fc5b9c8cc2d44e3b9e834472a841bdfe |
| institution | Directory Open Access Journal |
| issn | 2661-801X |
| language | English |
| last_indexed | 2024-03-12T22:20:21Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Chemistry |
| spelling | doaj.art-fc5b9c8cc2d44e3b9e834472a841bdfe2023-07-23T11:05:38ZengBMCBMC Chemistry2661-801X2023-07-0117111010.1186/s13065-023-01002-4Green microwave quantum dots as luminescent probes for quantifying prucalopride: consistency of content and application to pharmacokinetic studiesBaher I. Salman0Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar UniversityAbstract Prucalopride (PCP) is a medication used for the management of constipation via regulating bowel motions. PCP is widely used all over the world. So, novel, rapid, and highly sensitive carbon dots N-CQDs were obtained from Eruca Sativa juice via microwave approach in 4 min. The luminescence power of N-CQDs was declined by the increasing prucalopride concentration at emission 518 nm with linearity ranged from 3.00 to 200.00 ng mL−1. The luminescent antecedent was utilized for the test of PCP in human plasma with the rate of recovery extending from 95.06 to 98.40%. The new technique is an eco-friendly analytical method that can be easily applied in clinical laboratories. This assay is also simple, sensitive, and applied to therapeutic laboratories and subsequent pharmacokinetic studies in several clinical laboratories. Furthermore, the N-CQDs nano-sensor was able to distinguish the target drug from interferents commonly found in human plasma, indicating its high specificity and selectivity for PCP detection.https://doi.org/10.1186/s13065-023-01002-4PrucaloprideN-CQDsFluorescenceHuman plasmaContent uniformity |
| spellingShingle | Baher I. Salman Green microwave quantum dots as luminescent probes for quantifying prucalopride: consistency of content and application to pharmacokinetic studies BMC Chemistry Prucalopride N-CQDs Fluorescence Human plasma Content uniformity |
| title | Green microwave quantum dots as luminescent probes for quantifying prucalopride: consistency of content and application to pharmacokinetic studies |
| title_full | Green microwave quantum dots as luminescent probes for quantifying prucalopride: consistency of content and application to pharmacokinetic studies |
| title_fullStr | Green microwave quantum dots as luminescent probes for quantifying prucalopride: consistency of content and application to pharmacokinetic studies |
| title_full_unstemmed | Green microwave quantum dots as luminescent probes for quantifying prucalopride: consistency of content and application to pharmacokinetic studies |
| title_short | Green microwave quantum dots as luminescent probes for quantifying prucalopride: consistency of content and application to pharmacokinetic studies |
| title_sort | green microwave quantum dots as luminescent probes for quantifying prucalopride consistency of content and application to pharmacokinetic studies |
| topic | Prucalopride N-CQDs Fluorescence Human plasma Content uniformity |
| url | https://doi.org/10.1186/s13065-023-01002-4 |
| work_keys_str_mv | AT baherisalman greenmicrowavequantumdotsasluminescentprobesforquantifyingprucaloprideconsistencyofcontentandapplicationtopharmacokineticstudies |