Association of gene polymorphisms with women urinary incontinence
Aim of study was set to investigate the association of women urinary incontinence (UI) with serotonin receptor HTR2A T102C and beta 3-adrenergic receptor ADRB3 Trp64Arg genes polymorphisms. The study included 110 women with Urge, Stress, and Mixed UI types and the control group – 105 continent women...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2021-08-01
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| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2021-0332 |
| _version_ | 1797998412524683264 |
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| author | Aniulis Povilas Podlipskyte Aurelija Smalinskiene Alina Aniuliene Rosita Jievaltas Mindaugas |
| author_facet | Aniulis Povilas Podlipskyte Aurelija Smalinskiene Alina Aniuliene Rosita Jievaltas Mindaugas |
| author_sort | Aniulis Povilas |
| collection | DOAJ |
| description | Aim of study was set to investigate the association of women urinary incontinence (UI) with serotonin receptor HTR2A T102C and beta 3-adrenergic receptor ADRB3 Trp64Arg genes polymorphisms. The study included 110 women with Urge, Stress, and Mixed UI types and the control group – 105 continent women. Both groups have filled in the ICIQ-FLUTS questionnaire and their blood genotyping was performed. Urge UI subgroup was older and had higher body mass index (BMI) in comparison to other UI types and control group. More than half of all women had family history of UI in Stress UI and Mixed UI subgroups. The frequency of HTR2A T102C gene polymorphism’s minor allele C and genotype CC was significantly more expressed in Urge UI subgroup, as compared with control group (C-77.3 vs 58.7%, p = 0.007 and CC-57.6 vs 31.1%, p = 0.015). The ADRB3 Trp64Arg gene polymorphism did not differ between groups. The regression analysis revealed CC genotype (OR = 3.06, 95% CI: 1.11–8.43; p = 0.030) and allele C (OR = 2.53, 95% CI: 1.16–5.53; p = 0.020) were risk factors for development of Urge UI. We conclude that HTR2A T102C gene polymorphism affected the development of Urge UI. |
| first_indexed | 2024-04-11T10:47:15Z |
| format | Article |
| id | doaj.art-fc5cb8d28574454bbd0c62907090e79b |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-11T10:47:15Z |
| publishDate | 2021-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-fc5cb8d28574454bbd0c62907090e79b2022-12-22T04:29:00ZengDe GruyterOpen Medicine2391-54632021-08-011611190119710.1515/med-2021-0332Association of gene polymorphisms with women urinary incontinenceAniulis Povilas0Podlipskyte Aurelija1Smalinskiene Alina2Aniuliene Rosita3Jievaltas Mindaugas4Urology Clinic, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus Str. 9, Kaunas LT-44307, LithuaniaLaboratory of Behavioral Medicine, Neuroscience Institute, Lithuanian University of Health Sciences, Palanga LT-00135, LithuaniaInstitute of Biology Systems And Genetic Research, Lithuanian University Of Health Sciences, Kaunas LT-44307, LithuaniaObstetrics And Gynecology Clinic, Medical Academy, Lithuanian University of Health Sciences, Kaunas LT-44307, LithuaniaUrology Clinic, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus Str. 9, Kaunas LT-44307, LithuaniaAim of study was set to investigate the association of women urinary incontinence (UI) with serotonin receptor HTR2A T102C and beta 3-adrenergic receptor ADRB3 Trp64Arg genes polymorphisms. The study included 110 women with Urge, Stress, and Mixed UI types and the control group – 105 continent women. Both groups have filled in the ICIQ-FLUTS questionnaire and their blood genotyping was performed. Urge UI subgroup was older and had higher body mass index (BMI) in comparison to other UI types and control group. More than half of all women had family history of UI in Stress UI and Mixed UI subgroups. The frequency of HTR2A T102C gene polymorphism’s minor allele C and genotype CC was significantly more expressed in Urge UI subgroup, as compared with control group (C-77.3 vs 58.7%, p = 0.007 and CC-57.6 vs 31.1%, p = 0.015). The ADRB3 Trp64Arg gene polymorphism did not differ between groups. The regression analysis revealed CC genotype (OR = 3.06, 95% CI: 1.11–8.43; p = 0.030) and allele C (OR = 2.53, 95% CI: 1.16–5.53; p = 0.020) were risk factors for development of Urge UI. We conclude that HTR2A T102C gene polymorphism affected the development of Urge UI.https://doi.org/10.1515/med-2021-0332adrb3htr2aserotonin receptor 2agene polymorphismui |
| spellingShingle | Aniulis Povilas Podlipskyte Aurelija Smalinskiene Alina Aniuliene Rosita Jievaltas Mindaugas Association of gene polymorphisms with women urinary incontinence Open Medicine adrb3 htr2a serotonin receptor 2a gene polymorphism ui |
| title | Association of gene polymorphisms with women urinary incontinence |
| title_full | Association of gene polymorphisms with women urinary incontinence |
| title_fullStr | Association of gene polymorphisms with women urinary incontinence |
| title_full_unstemmed | Association of gene polymorphisms with women urinary incontinence |
| title_short | Association of gene polymorphisms with women urinary incontinence |
| title_sort | association of gene polymorphisms with women urinary incontinence |
| topic | adrb3 htr2a serotonin receptor 2a gene polymorphism ui |
| url | https://doi.org/10.1515/med-2021-0332 |
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