Cadherin-12 Regulates Neurite Outgrowth Through the PKA/Rac1/Cdc42 Pathway in Cortical Neurons

Cadherin-12 Regulates Neurite Outgrowth Through the PKA/Rac1/Cdc42 Pathway in Cortical Neurons

Cadherins play an important role in tissue homeostasis, as they are responsible for cell-cell adhesion during embryogenesis, tissue morphogenesis, and differentiation. In this study, we identified Cadherin-12 (CDH12), which encodes a type II classical cadherin, as a gene that promotes neurite outgro...

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Bibliographic Details
Main Authors: Beibei Guo, Mengwei Qi, Shuai Huang, Run Zhuo, Wenxue Zhang, Yufang Zhang, Man Xu, Mei Liu, Tuchen Guan, Yan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Cadherin-12
neurite outgrowth
cAMP/PKA pathway
Rac1/Cdc42
NgAgo
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.768970/full

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