Extracellular Lactate Acts as a Metabolic Checkpoint and Shapes Monocyte Function Time Dependently

Extracellular Lactate Acts as a Metabolic Checkpoint and Shapes Monocyte Function Time Dependently

Elevated blood lactate levels are frequently found in critically ill patients and thought to result from tissue hypoperfusion and cellular oxygen shortage. Considering the close relationship between immune cell function and intracellular metabolism, lactate is more than a glycolytic waste molecule b...

Full description

Bibliographic Details
Main Authors: Judith Schenz, Lena Heilig, Tim Lohse, Lucas Tichy, Katharina Bomans, Michael Büttner, Markus A. Weigand, Florian Uhle
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
critically ill
glycolysis
immunometabolism
polyol pathway
sepsis
sorbitol
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.729209/full

Similar Items

Similar Items