Retrospective molecular investigation of Mayaro and Oropouche viruses at the human-animal interface in West-central Brazil, 2016-2018.
Mayaro virus (MAYV, Togaviridae) and Oropouche orthobunyavirus (OROV, Peribunyaviridae) are emerging enzootic arboviruses in Latin America. Outbreaks of febrile illness associated with MAYV and OROV have been reported among humans mainly in the northern region of Brazil since the 1980s, and recent d...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0277612 |
| _version_ | 1797959093255667712 |
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| author | Helver Gonçalves Dias Raquel Curtinhas de Lima Luciana Santos Barbosa Thiara Manuele Alves de Souza Jessica Badolato-Correa Laura Marina Siqueira Maia Raquel da Silva Ferreira Nilvanei Aparecido da Silva Neves Michell Charlles de Souza Costa Leticia Ramos Martins Emerson Marques de Souza Michellen Dos Santos Carvalho Alexandre de Araujo-Oliveira William de Almeida Marques Gilberto Sabino-Santos Marcio Schafer Marques Gabriel Carvalho de Macedo Wesley Arruda Gimenes Nantes Filipe Martins Santos Claudia Coutinho Netto Thais Oliveira Morgado Mateus de Assis Bianchini Sandra Helena Ramiro Correa Júlia Ramos de Almeida Larissa Pratta Campos Isabelle Marino de Souza Wanessa Teixeira Gomes Barreto Grasiela Porfírio Jeronimo Augusto Fonseca Alencar Heitor Miraglia Herrera Renata Dezengrini Shlessarenko Rivaldo Venancio da Cunha Elzinandes Leal de Azeredo Stephanie J Salyer Nicholas Komar Alex Pauvolid-Corrêa Flávia Barreto Dos Santos |
| author_facet | Helver Gonçalves Dias Raquel Curtinhas de Lima Luciana Santos Barbosa Thiara Manuele Alves de Souza Jessica Badolato-Correa Laura Marina Siqueira Maia Raquel da Silva Ferreira Nilvanei Aparecido da Silva Neves Michell Charlles de Souza Costa Leticia Ramos Martins Emerson Marques de Souza Michellen Dos Santos Carvalho Alexandre de Araujo-Oliveira William de Almeida Marques Gilberto Sabino-Santos Marcio Schafer Marques Gabriel Carvalho de Macedo Wesley Arruda Gimenes Nantes Filipe Martins Santos Claudia Coutinho Netto Thais Oliveira Morgado Mateus de Assis Bianchini Sandra Helena Ramiro Correa Júlia Ramos de Almeida Larissa Pratta Campos Isabelle Marino de Souza Wanessa Teixeira Gomes Barreto Grasiela Porfírio Jeronimo Augusto Fonseca Alencar Heitor Miraglia Herrera Renata Dezengrini Shlessarenko Rivaldo Venancio da Cunha Elzinandes Leal de Azeredo Stephanie J Salyer Nicholas Komar Alex Pauvolid-Corrêa Flávia Barreto Dos Santos |
| author_sort | Helver Gonçalves Dias |
| collection | DOAJ |
| description | Mayaro virus (MAYV, Togaviridae) and Oropouche orthobunyavirus (OROV, Peribunyaviridae) are emerging enzootic arboviruses in Latin America. Outbreaks of febrile illness associated with MAYV and OROV have been reported among humans mainly in the northern region of Brazil since the 1980s, and recent data suggest these viruses have circulated also in more populated areas of western Brazil. MAYV shares mosquito vectors with yellow fever virus and it has been historically detected during yellow fever epidemics. Aiming to investigate the transmission of OROV and MAYV at the human-animal interface during a yellow fever, chikungunya and Zika outbreaks in Brazil, we conducted a retrospective molecular investigation in 810 wild and domestic animals, 106 febrile patients, and 22.931 vectors collected from 2016 to 2018 in Cuiaba and Campo Grande metropolitan regions, western Brazil. All samples tested negative for OROV and MAYV RNA by RT-qPCR. Findings presented here suggest no active circulation of MAYV and OROV in the sampled hosts. Active surveillance and retrospective investigations are instrumental approaches for the detection of cryptic and subclinical activity of enzootic arboviruses and together serve as a warning system to implement appropriate actions to prevent outbreaks. |
| first_indexed | 2024-04-11T00:29:00Z |
| format | Article |
| id | doaj.art-fc6896d6c96d414ea78d8ba347c63502 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T00:29:00Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-fc6896d6c96d414ea78d8ba347c635022023-01-08T05:31:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011711e027761210.1371/journal.pone.0277612Retrospective molecular investigation of Mayaro and Oropouche viruses at the human-animal interface in West-central Brazil, 2016-2018.Helver Gonçalves DiasRaquel Curtinhas de LimaLuciana Santos BarbosaThiara Manuele Alves de SouzaJessica Badolato-CorreaLaura Marina Siqueira MaiaRaquel da Silva FerreiraNilvanei Aparecido da Silva NevesMichell Charlles de Souza CostaLeticia Ramos MartinsEmerson Marques de SouzaMichellen Dos Santos CarvalhoAlexandre de Araujo-OliveiraWilliam de Almeida MarquesGilberto Sabino-SantosMarcio Schafer MarquesGabriel Carvalho de MacedoWesley Arruda Gimenes NantesFilipe Martins SantosClaudia Coutinho NettoThais Oliveira MorgadoMateus de Assis BianchiniSandra Helena Ramiro CorreaJúlia Ramos de AlmeidaLarissa Pratta CamposIsabelle Marino de SouzaWanessa Teixeira Gomes BarretoGrasiela PorfírioJeronimo Augusto Fonseca AlencarHeitor Miraglia HerreraRenata Dezengrini ShlessarenkoRivaldo Venancio da CunhaElzinandes Leal de AzeredoStephanie J SalyerNicholas KomarAlex Pauvolid-CorrêaFlávia Barreto Dos SantosMayaro virus (MAYV, Togaviridae) and Oropouche orthobunyavirus (OROV, Peribunyaviridae) are emerging enzootic arboviruses in Latin America. Outbreaks of febrile illness associated with MAYV and OROV have been reported among humans mainly in the northern region of Brazil since the 1980s, and recent data suggest these viruses have circulated also in more populated areas of western Brazil. MAYV shares mosquito vectors with yellow fever virus and it has been historically detected during yellow fever epidemics. Aiming to investigate the transmission of OROV and MAYV at the human-animal interface during a yellow fever, chikungunya and Zika outbreaks in Brazil, we conducted a retrospective molecular investigation in 810 wild and domestic animals, 106 febrile patients, and 22.931 vectors collected from 2016 to 2018 in Cuiaba and Campo Grande metropolitan regions, western Brazil. All samples tested negative for OROV and MAYV RNA by RT-qPCR. Findings presented here suggest no active circulation of MAYV and OROV in the sampled hosts. Active surveillance and retrospective investigations are instrumental approaches for the detection of cryptic and subclinical activity of enzootic arboviruses and together serve as a warning system to implement appropriate actions to prevent outbreaks.https://doi.org/10.1371/journal.pone.0277612 |
| spellingShingle | Helver Gonçalves Dias Raquel Curtinhas de Lima Luciana Santos Barbosa Thiara Manuele Alves de Souza Jessica Badolato-Correa Laura Marina Siqueira Maia Raquel da Silva Ferreira Nilvanei Aparecido da Silva Neves Michell Charlles de Souza Costa Leticia Ramos Martins Emerson Marques de Souza Michellen Dos Santos Carvalho Alexandre de Araujo-Oliveira William de Almeida Marques Gilberto Sabino-Santos Marcio Schafer Marques Gabriel Carvalho de Macedo Wesley Arruda Gimenes Nantes Filipe Martins Santos Claudia Coutinho Netto Thais Oliveira Morgado Mateus de Assis Bianchini Sandra Helena Ramiro Correa Júlia Ramos de Almeida Larissa Pratta Campos Isabelle Marino de Souza Wanessa Teixeira Gomes Barreto Grasiela Porfírio Jeronimo Augusto Fonseca Alencar Heitor Miraglia Herrera Renata Dezengrini Shlessarenko Rivaldo Venancio da Cunha Elzinandes Leal de Azeredo Stephanie J Salyer Nicholas Komar Alex Pauvolid-Corrêa Flávia Barreto Dos Santos Retrospective molecular investigation of Mayaro and Oropouche viruses at the human-animal interface in West-central Brazil, 2016-2018. PLoS ONE |
| title | Retrospective molecular investigation of Mayaro and Oropouche viruses at the human-animal interface in West-central Brazil, 2016-2018. |
| title_full | Retrospective molecular investigation of Mayaro and Oropouche viruses at the human-animal interface in West-central Brazil, 2016-2018. |
| title_fullStr | Retrospective molecular investigation of Mayaro and Oropouche viruses at the human-animal interface in West-central Brazil, 2016-2018. |
| title_full_unstemmed | Retrospective molecular investigation of Mayaro and Oropouche viruses at the human-animal interface in West-central Brazil, 2016-2018. |
| title_short | Retrospective molecular investigation of Mayaro and Oropouche viruses at the human-animal interface in West-central Brazil, 2016-2018. |
| title_sort | retrospective molecular investigation of mayaro and oropouche viruses at the human animal interface in west central brazil 2016 2018 |
| url | https://doi.org/10.1371/journal.pone.0277612 |
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