A frequent SNP in TRIM5α strongly enhances the innate immune response against LINE-1 elements

A frequent SNP in TRIM5α strongly enhances the innate immune response against LINE-1 elements

The intracellular restriction factor TRIM5α inhibits endogenous LINE-1 retroelements. It induces innate immune signaling cascades upon sensing of cytoplasmic LINE-1 complexes, thereby underlining its importance for protecting the human genome from harmful retrotransposition events. Here, we show tha...

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Bibliographic Details
Main Authors: Justine Lagisquet, Marcus Conrad, Sabine Wittmann, Bianca Volkmann, Hannah Weissinger, Heinrich Sticht, Thomas Gramberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
TRIM5α
LINE-1
retroelements
NF-κB
AP-1
restriction factor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1168589/full

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