Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody
Angiopoietin (Angpt)-Tie receptor 2 (Tie2) regulates vascular stability and is thus a potential therapeutic target in vascular diseases. Here, the authors report a Tie2-agonistic antibody which targets a site distinct from the Angpt 1-binding site and which influences Tie2 clustering and activation...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26620-1 |
| _version_ | 1818823325197008896 |
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| author | Gyunghee Jo Jeomil Bae Ho Jeong Hong Ah-reum Han Do-Kyun Kim Seon Pyo Hong Jung A Kim Sangkyu Lee Gou Young Koh Ho Min Kim |
| author_facet | Gyunghee Jo Jeomil Bae Ho Jeong Hong Ah-reum Han Do-Kyun Kim Seon Pyo Hong Jung A Kim Sangkyu Lee Gou Young Koh Ho Min Kim |
| author_sort | Gyunghee Jo |
| collection | DOAJ |
| description | Angiopoietin (Angpt)-Tie receptor 2 (Tie2) regulates vascular stability and is thus a potential therapeutic target in vascular diseases. Here, the authors report a Tie2-agonistic antibody which targets a site distinct from the Angpt 1-binding site and which influences Tie2 clustering and activation in an Angpt2 inhibition-resistant manner. |
| first_indexed | 2024-12-18T23:38:11Z |
| format | Article |
| id | doaj.art-fc69bcd280cf4fe0bfa69e52efbb0a96 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T23:38:11Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fc69bcd280cf4fe0bfa69e52efbb0a962022-12-21T20:47:29ZengNature PortfolioNature Communications2041-17232021-11-0112111810.1038/s41467-021-26620-1Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibodyGyunghee Jo0Jeomil Bae1Ho Jeong Hong2Ah-reum Han3Do-Kyun Kim4Seon Pyo Hong5Jung A Kim6Sangkyu Lee7Gou Young Koh8Ho Min Kim9Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Center for Vascular Research, IBSCenter for Biomolecular & Cellular Structure, Institute for Basic Science (IBS)Center for Biomolecular & Cellular Structure, Institute for Basic Science (IBS)Center for Biomolecular & Cellular Structure, Institute for Basic Science (IBS)Center for Vascular Research, IBSGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Center for Cognition and Sociality, IBSGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Angiopoietin (Angpt)-Tie receptor 2 (Tie2) regulates vascular stability and is thus a potential therapeutic target in vascular diseases. Here, the authors report a Tie2-agonistic antibody which targets a site distinct from the Angpt 1-binding site and which influences Tie2 clustering and activation in an Angpt2 inhibition-resistant manner.https://doi.org/10.1038/s41467-021-26620-1 |
| spellingShingle | Gyunghee Jo Jeomil Bae Ho Jeong Hong Ah-reum Han Do-Kyun Kim Seon Pyo Hong Jung A Kim Sangkyu Lee Gou Young Koh Ho Min Kim Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody Nature Communications |
| title | Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody |
| title_full | Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody |
| title_fullStr | Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody |
| title_full_unstemmed | Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody |
| title_short | Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody |
| title_sort | structural insights into the clustering and activation of tie2 receptor mediated by tie2 agonistic antibody |
| url | https://doi.org/10.1038/s41467-021-26620-1 |
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