P-TEFb as A Promising Therapeutic Target
The positive transcription elongation factor b (P-TEFb) was first identified as a general factor that stimulates transcription elongation by RNA polymerase II (RNAPII), but soon afterwards it turned out to be an essential cellular co-factor of human immunodeficiency virus (HIV) transcription mediate...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/4/838 |
| _version_ | 1828430206245797888 |
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| author | Koh Fujinaga |
| author_facet | Koh Fujinaga |
| author_sort | Koh Fujinaga |
| collection | DOAJ |
| description | The positive transcription elongation factor b (P-TEFb) was first identified as a general factor that stimulates transcription elongation by RNA polymerase II (RNAPII), but soon afterwards it turned out to be an essential cellular co-factor of human immunodeficiency virus (HIV) transcription mediated by viral Tat proteins. Studies on the mechanisms of Tat-dependent HIV transcription have led to radical advances in our knowledge regarding the mechanism of eukaryotic transcription, including the discoveries that P-TEFb-mediated elongation control of cellular transcription is a main regulatory step of gene expression in eukaryotes, and deregulation of P-TEFb activity plays critical roles in many human diseases and conditions in addition to HIV/AIDS. P-TEFb is now recognized as an attractive and promising therapeutic target for inflammation/autoimmune diseases, cardiac hypertrophy, cancer, infectious diseases, etc. In this review article, I will summarize our knowledge about basic P-TEFb functions, the regulatory mechanism of P-TEFb-dependent transcription, P-TEFb’s involvement in biological processes and diseases, and current approaches to manipulating P-TEFb functions for the treatment of these diseases. |
| first_indexed | 2024-12-10T17:45:14Z |
| format | Article |
| id | doaj.art-fc6cf4e624af47bebad2b030ee0ec70c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-10T17:45:14Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-fc6cf4e624af47bebad2b030ee0ec70c2022-12-22T01:39:16ZengMDPI AGMolecules1420-30492020-02-0125483810.3390/molecules25040838molecules25040838P-TEFb as A Promising Therapeutic TargetKoh Fujinaga0Department of Medicine, University of California, San Francisco, CA 94143-0703, USAThe positive transcription elongation factor b (P-TEFb) was first identified as a general factor that stimulates transcription elongation by RNA polymerase II (RNAPII), but soon afterwards it turned out to be an essential cellular co-factor of human immunodeficiency virus (HIV) transcription mediated by viral Tat proteins. Studies on the mechanisms of Tat-dependent HIV transcription have led to radical advances in our knowledge regarding the mechanism of eukaryotic transcription, including the discoveries that P-TEFb-mediated elongation control of cellular transcription is a main regulatory step of gene expression in eukaryotes, and deregulation of P-TEFb activity plays critical roles in many human diseases and conditions in addition to HIV/AIDS. P-TEFb is now recognized as an attractive and promising therapeutic target for inflammation/autoimmune diseases, cardiac hypertrophy, cancer, infectious diseases, etc. In this review article, I will summarize our knowledge about basic P-TEFb functions, the regulatory mechanism of P-TEFb-dependent transcription, P-TEFb’s involvement in biological processes and diseases, and current approaches to manipulating P-TEFb functions for the treatment of these diseases.https://www.mdpi.com/1420-3049/25/4/838p-tefbtranscription elongationhivcancercardiac hypertrophyrna polymerase iiinfectious diseasesinflammationautoimmune diseasesinhibitors |
| spellingShingle | Koh Fujinaga P-TEFb as A Promising Therapeutic Target Molecules p-tefb transcription elongation hiv cancer cardiac hypertrophy rna polymerase ii infectious diseases inflammation autoimmune diseases inhibitors |
| title | P-TEFb as A Promising Therapeutic Target |
| title_full | P-TEFb as A Promising Therapeutic Target |
| title_fullStr | P-TEFb as A Promising Therapeutic Target |
| title_full_unstemmed | P-TEFb as A Promising Therapeutic Target |
| title_short | P-TEFb as A Promising Therapeutic Target |
| title_sort | p tefb as a promising therapeutic target |
| topic | p-tefb transcription elongation hiv cancer cardiac hypertrophy rna polymerase ii infectious diseases inflammation autoimmune diseases inhibitors |
| url | https://www.mdpi.com/1420-3049/25/4/838 |
| work_keys_str_mv | AT kohfujinaga ptefbasapromisingtherapeutictarget |