Different prevalence and spectrum of malignancy between Chinese patients and American patients with rheumatoid arthritis: a comparative study
Objective To characterize the epidemiological characteristics of malignancy in Chinese patients with rheumatoid arthritis (RA) versus American patients and investigate their associated factors. Methods Data were collected from a real-world Chinese RA population and American patients with RA from the...
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PeerJ Inc.
2024-12-01
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| Online Access: | https://peerj.com/articles/18650.pdf |
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| author | Zhi-Ming Ouyang Yao-Wei Zou Jie Pan Ye Lu Ying Yang Qian-Hua Li Jian-Da Ma Pei-Wen Jia Tao Wu Yu-Ting Fan Jian-Zi Lin Xiu-Ning Wei Kui-Min Yang Yun Su Lie Dai |
| author_facet | Zhi-Ming Ouyang Yao-Wei Zou Jie Pan Ye Lu Ying Yang Qian-Hua Li Jian-Da Ma Pei-Wen Jia Tao Wu Yu-Ting Fan Jian-Zi Lin Xiu-Ning Wei Kui-Min Yang Yun Su Lie Dai |
| author_sort | Zhi-Ming Ouyang |
| collection | DOAJ |
| description | Objective To characterize the epidemiological characteristics of malignancy in Chinese patients with rheumatoid arthritis (RA) versus American patients and investigate their associated factors. Methods Data were collected from a real-world Chinese RA population and American patients with RA from the National Health and Nutritional Examination Survey. The prevalence and subtypes of malignancy and their potential associated factors were investigated in both populations. Results A total of 2,073 Chinese and 2,928 American patients with RA were included. There was a lower prevalence of malignancy in Chinese than in their American counterparts before (5.7% vs. 17.1%) and after matching (6.2% vs. 12.6%, both P < 0.001). Gender discrepancies in malignancy prevalence were observed, with a male predilection for RA with malignancy in China (8.2% vs. 5.5%), while it was the opposite in American patients (10.1% vs. 13.5%, both P < 0.05). The top type of malignancy among male patients with RA was lung cancer in Chinese (2.29%), but non-melanoma skin cancer (3.43%) in American; while among female patients was breast cancer both in Chinese (1.72%) and American (3.43%). Multivariate logistic regression analyses showed that older age (odds ratio (OR) = 1.050) and positive anti-cyclic citrullinated peptide antibody (OR = 2.752) were independently associated with malignancy in Chinese patients with RA, while female (OR = 1.395), older age (OR = 1.033), active smoking (OR = 1.580) and cardiovascular diseases (OR = 1.523) in American patients. Conclusion The prevalence, subtypes and risk factors of malignancy were substantially different in Chinese patients with RA and their American counterparts, which implied the importance of individualized malignancy screening strategies for patients with RA. |
| first_indexed | 2025-02-17T15:05:59Z |
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| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2025-02-17T15:05:59Z |
| publishDate | 2024-12-01 |
| publisher | PeerJ Inc. |
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| spelling | doaj.art-fc6d69279e2b49b4843fef8a4df1b2e72024-12-20T15:05:10ZengPeerJ Inc.PeerJ2167-83592024-12-0112e1865010.7717/peerj.18650Different prevalence and spectrum of malignancy between Chinese patients and American patients with rheumatoid arthritis: a comparative studyZhi-Ming Ouyang0Yao-Wei Zou1Jie Pan2Ye Lu3Ying Yang4Qian-Hua Li5Jian-Da Ma6Pei-Wen Jia7Tao Wu8Yu-Ting Fan9Jian-Zi Lin10Xiu-Ning Wei11Kui-Min Yang12Yun Su13Lie Dai14Department of Rheumatology and Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Rheumatology and Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Rheumatology and Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Rheumatology and Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Rheumatology and Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Rheumatology and Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Rheumatology and Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Rheumatology and Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Rheumatology and Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Rheumatology and Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Rheumatology and Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Rheumatology and Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Rheumatology and Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaZhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Rheumatology and Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaObjective To characterize the epidemiological characteristics of malignancy in Chinese patients with rheumatoid arthritis (RA) versus American patients and investigate their associated factors. Methods Data were collected from a real-world Chinese RA population and American patients with RA from the National Health and Nutritional Examination Survey. The prevalence and subtypes of malignancy and their potential associated factors were investigated in both populations. Results A total of 2,073 Chinese and 2,928 American patients with RA were included. There was a lower prevalence of malignancy in Chinese than in their American counterparts before (5.7% vs. 17.1%) and after matching (6.2% vs. 12.6%, both P < 0.001). Gender discrepancies in malignancy prevalence were observed, with a male predilection for RA with malignancy in China (8.2% vs. 5.5%), while it was the opposite in American patients (10.1% vs. 13.5%, both P < 0.05). The top type of malignancy among male patients with RA was lung cancer in Chinese (2.29%), but non-melanoma skin cancer (3.43%) in American; while among female patients was breast cancer both in Chinese (1.72%) and American (3.43%). Multivariate logistic regression analyses showed that older age (odds ratio (OR) = 1.050) and positive anti-cyclic citrullinated peptide antibody (OR = 2.752) were independently associated with malignancy in Chinese patients with RA, while female (OR = 1.395), older age (OR = 1.033), active smoking (OR = 1.580) and cardiovascular diseases (OR = 1.523) in American patients. Conclusion The prevalence, subtypes and risk factors of malignancy were substantially different in Chinese patients with RA and their American counterparts, which implied the importance of individualized malignancy screening strategies for patients with RA.https://peerj.com/articles/18650.pdfRheumatoid arthritisMalignancyChineseAmerican |
| spellingShingle | Zhi-Ming Ouyang Yao-Wei Zou Jie Pan Ye Lu Ying Yang Qian-Hua Li Jian-Da Ma Pei-Wen Jia Tao Wu Yu-Ting Fan Jian-Zi Lin Xiu-Ning Wei Kui-Min Yang Yun Su Lie Dai Different prevalence and spectrum of malignancy between Chinese patients and American patients with rheumatoid arthritis: a comparative study PeerJ Rheumatoid arthritis Malignancy Chinese American |
| title | Different prevalence and spectrum of malignancy between Chinese patients and American patients with rheumatoid arthritis: a comparative study |
| title_full | Different prevalence and spectrum of malignancy between Chinese patients and American patients with rheumatoid arthritis: a comparative study |
| title_fullStr | Different prevalence and spectrum of malignancy between Chinese patients and American patients with rheumatoid arthritis: a comparative study |
| title_full_unstemmed | Different prevalence and spectrum of malignancy between Chinese patients and American patients with rheumatoid arthritis: a comparative study |
| title_short | Different prevalence and spectrum of malignancy between Chinese patients and American patients with rheumatoid arthritis: a comparative study |
| title_sort | different prevalence and spectrum of malignancy between chinese patients and american patients with rheumatoid arthritis a comparative study |
| topic | Rheumatoid arthritis Malignancy Chinese American |
| url | https://peerj.com/articles/18650.pdf |
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