SARS-CoV-2 specific serological pattern in healthcare workers of an Italian COVID-19 forefront hospital
Abstract Background COVID-19 is an infectious disease caused by a novel coronavirus (SARS-CoV-2). The immunopathogenesis of the infection is currently unknown. Healthcare workers (HCWs) are at highest risk of infection and disease. Aim of the study was to assess the sero-prevalence of SARS-CoV-2 in...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12890-020-01237-0 |
| _version_ | 1811337369842876416 |
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| author | Giovanni Sotgiu Alessandra Barassi Monica Miozzo Laura Saderi Andrea Piana Nicola Orfeo Claudio Colosio Giovanni Felisati Matteo Davì Alberto Giovanni Gerli Stefano Centanni |
| author_facet | Giovanni Sotgiu Alessandra Barassi Monica Miozzo Laura Saderi Andrea Piana Nicola Orfeo Claudio Colosio Giovanni Felisati Matteo Davì Alberto Giovanni Gerli Stefano Centanni |
| author_sort | Giovanni Sotgiu |
| collection | DOAJ |
| description | Abstract Background COVID-19 is an infectious disease caused by a novel coronavirus (SARS-CoV-2). The immunopathogenesis of the infection is currently unknown. Healthcare workers (HCWs) are at highest risk of infection and disease. Aim of the study was to assess the sero-prevalence of SARS-CoV-2 in an Italian cohort of HCWs exposed to COVID-19 patients. Methods A point-of-care lateral flow immunoassay (BioMedomics IgM-IgG Combined Antibody Rapid Test) was adopted to assess the prevalence of IgG and IgM against SARS-CoV-2. It was ethically approved (“Milano Area 1” Ethical Committee prot. n. 2020/ST/057). Results A total of 202 individuals (median age 45 years; 34.7% males) were retrospectively recruited in an Italian hospital (Milan, Italy). The percentage (95% CI) of recruited individuals with IgM and IgG were 14.4% (9.6–19.2%) and 7.4% (3.8–11.0%), respectively. IgM were more frequently found in males (24.3%), and in individuals aged 20–29 (25.9%) and 60–69 (30.4%) years. No relationship was found between exposure to COVID-19 patients and IgM and IgG positivity. Conclusions The present study did show a low prevalence of SARS-CoV-2 IgM in Italian HCWs. New studies are needed to assess the prevalence of SARS-CoV-2 antibodies in HCWs exposed to COVID-19 patients, as well the role of neutralizing antibodies. |
| first_indexed | 2024-04-13T17:53:53Z |
| format | Article |
| id | doaj.art-fc6e072823fd4431b23bc4ba62cbcb1b |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-13T17:53:53Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-fc6e072823fd4431b23bc4ba62cbcb1b2022-12-22T02:36:35ZengBMCBMC Pulmonary Medicine1471-24662020-07-012011610.1186/s12890-020-01237-0SARS-CoV-2 specific serological pattern in healthcare workers of an Italian COVID-19 forefront hospitalGiovanni Sotgiu0Alessandra Barassi1Monica Miozzo2Laura Saderi3Andrea Piana4Nicola Orfeo5Claudio Colosio6Giovanni Felisati7Matteo Davì8Alberto Giovanni Gerli9Stefano Centanni10Clinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical, Experimental Sciences, University of SassariLaboratory of Clinical Chemistry, ASST Santi Paolo e Carlo, San Paolo Hospital, Department of Health Sciences, Università degli Studi di MilanoDepartment of Pathophysiology and Transplantation, Università degli Studi di MilanoClinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical, Experimental Sciences, University of SassariClinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical, Experimental Sciences, University of SassariMedical Direction ASST Santi Paolo e CarloOccupational Health Unit, International Center for Rural Health, ASST Santi Paolo e Carlo, Department of Health Sciences, Università degli Studi di MilanoHead and Neck Dapartment, ASST Santi Paolo e Carlo, San Paolo Hospital, Department of Health Sciences, Università degli Studi di MilanoRespiratory Unit, ASST Santi Paolo e Carlo, San Paolo Hospital, Department of Health Sciences, Università degli Studi di MilanoManagement Engineering Tourbillon Tech srlRespiratory Unit, ASST Santi Paolo e Carlo, San Paolo Hospital, Department of Health Sciences, Università degli Studi di MilanoAbstract Background COVID-19 is an infectious disease caused by a novel coronavirus (SARS-CoV-2). The immunopathogenesis of the infection is currently unknown. Healthcare workers (HCWs) are at highest risk of infection and disease. Aim of the study was to assess the sero-prevalence of SARS-CoV-2 in an Italian cohort of HCWs exposed to COVID-19 patients. Methods A point-of-care lateral flow immunoassay (BioMedomics IgM-IgG Combined Antibody Rapid Test) was adopted to assess the prevalence of IgG and IgM against SARS-CoV-2. It was ethically approved (“Milano Area 1” Ethical Committee prot. n. 2020/ST/057). Results A total of 202 individuals (median age 45 years; 34.7% males) were retrospectively recruited in an Italian hospital (Milan, Italy). The percentage (95% CI) of recruited individuals with IgM and IgG were 14.4% (9.6–19.2%) and 7.4% (3.8–11.0%), respectively. IgM were more frequently found in males (24.3%), and in individuals aged 20–29 (25.9%) and 60–69 (30.4%) years. No relationship was found between exposure to COVID-19 patients and IgM and IgG positivity. Conclusions The present study did show a low prevalence of SARS-CoV-2 IgM in Italian HCWs. New studies are needed to assess the prevalence of SARS-CoV-2 antibodies in HCWs exposed to COVID-19 patients, as well the role of neutralizing antibodies.http://link.springer.com/article/10.1186/s12890-020-01237-0SeroprevalenceCOVID-19SARS-CoV-2IGHCWs |
| spellingShingle | Giovanni Sotgiu Alessandra Barassi Monica Miozzo Laura Saderi Andrea Piana Nicola Orfeo Claudio Colosio Giovanni Felisati Matteo Davì Alberto Giovanni Gerli Stefano Centanni SARS-CoV-2 specific serological pattern in healthcare workers of an Italian COVID-19 forefront hospital BMC Pulmonary Medicine Seroprevalence COVID-19 SARS-CoV-2 IG HCWs |
| title | SARS-CoV-2 specific serological pattern in healthcare workers of an Italian COVID-19 forefront hospital |
| title_full | SARS-CoV-2 specific serological pattern in healthcare workers of an Italian COVID-19 forefront hospital |
| title_fullStr | SARS-CoV-2 specific serological pattern in healthcare workers of an Italian COVID-19 forefront hospital |
| title_full_unstemmed | SARS-CoV-2 specific serological pattern in healthcare workers of an Italian COVID-19 forefront hospital |
| title_short | SARS-CoV-2 specific serological pattern in healthcare workers of an Italian COVID-19 forefront hospital |
| title_sort | sars cov 2 specific serological pattern in healthcare workers of an italian covid 19 forefront hospital |
| topic | Seroprevalence COVID-19 SARS-CoV-2 IG HCWs |
| url | http://link.springer.com/article/10.1186/s12890-020-01237-0 |
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