Behavioral Deficits in Animal Models of Blast Traumatic Brain Injury
Blast exposure has been identified to be the most common cause for traumatic brain injury (TBI) in soldiers. Over the years, rodent models to mimic blast exposures and the behavioral outcomes observed in veterans have been developed extensively. However, blast tube design and varying experimental pa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00990/full |
| _version_ | 1818523938081210368 |
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| author | Aswati Aravind Arun Reddy Ravula Namas Chandra Bryan J. Pfister |
| author_facet | Aswati Aravind Arun Reddy Ravula Namas Chandra Bryan J. Pfister |
| author_sort | Aswati Aravind |
| collection | DOAJ |
| description | Blast exposure has been identified to be the most common cause for traumatic brain injury (TBI) in soldiers. Over the years, rodent models to mimic blast exposures and the behavioral outcomes observed in veterans have been developed extensively. However, blast tube design and varying experimental parameters lead to inconsistencies in the behavioral outcomes reported across research laboratories. This review aims to curate the behavioral outcomes reported in rodent models of blast TBI using shockwave tubes or open field detonations between the years 2008–2019 and highlight the important experimental parameters that affect behavioral outcome. Further, we discuss the role of various design parameters of the blast tube that can affect the nature of blast exposure experienced by the rodents. Finally, we assess the most common behavioral tests done to measure cognitive, motor, anxiety, auditory, and fear conditioning deficits in blast TBI (bTBI) and discuss the advantages and disadvantages of these tests. |
| first_indexed | 2024-12-11T05:50:56Z |
| format | Article |
| id | doaj.art-fc6f6f320204485c9a288111e63d1d43 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-11T05:50:56Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-fc6f6f320204485c9a288111e63d1d432022-12-22T01:18:49ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-09-011110.3389/fneur.2020.00990543928Behavioral Deficits in Animal Models of Blast Traumatic Brain InjuryAswati AravindArun Reddy RavulaNamas ChandraBryan J. PfisterBlast exposure has been identified to be the most common cause for traumatic brain injury (TBI) in soldiers. Over the years, rodent models to mimic blast exposures and the behavioral outcomes observed in veterans have been developed extensively. However, blast tube design and varying experimental parameters lead to inconsistencies in the behavioral outcomes reported across research laboratories. This review aims to curate the behavioral outcomes reported in rodent models of blast TBI using shockwave tubes or open field detonations between the years 2008–2019 and highlight the important experimental parameters that affect behavioral outcome. Further, we discuss the role of various design parameters of the blast tube that can affect the nature of blast exposure experienced by the rodents. Finally, we assess the most common behavioral tests done to measure cognitive, motor, anxiety, auditory, and fear conditioning deficits in blast TBI (bTBI) and discuss the advantages and disadvantages of these tests.https://www.frontiersin.org/article/10.3389/fneur.2020.00990/fullblast TBIbehavior deficitscognitive deficitsanxiety and depressionmotor deficitsauditory deficits |
| spellingShingle | Aswati Aravind Arun Reddy Ravula Namas Chandra Bryan J. Pfister Behavioral Deficits in Animal Models of Blast Traumatic Brain Injury Frontiers in Neurology blast TBI behavior deficits cognitive deficits anxiety and depression motor deficits auditory deficits |
| title | Behavioral Deficits in Animal Models of Blast Traumatic Brain Injury |
| title_full | Behavioral Deficits in Animal Models of Blast Traumatic Brain Injury |
| title_fullStr | Behavioral Deficits in Animal Models of Blast Traumatic Brain Injury |
| title_full_unstemmed | Behavioral Deficits in Animal Models of Blast Traumatic Brain Injury |
| title_short | Behavioral Deficits in Animal Models of Blast Traumatic Brain Injury |
| title_sort | behavioral deficits in animal models of blast traumatic brain injury |
| topic | blast TBI behavior deficits cognitive deficits anxiety and depression motor deficits auditory deficits |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00990/full |
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