A Degenerate Peptide Library Approach to Reveal Sequence Determinants of Methyllysine-Driven Protein Interactions

A Degenerate Peptide Library Approach to Reveal Sequence Determinants of Methyllysine-Driven Protein Interactions

Lysine methylation facilitates protein-protein interactions through the activity of methyllysine (Kme) “reader” proteins. Functions of Kme readers have historically been studied in the context of histone interactions, where readers aid in chromatin-templated processes such as transcription, DNA repl...

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Bibliographic Details
Main Authors: Ariana Kupai, Robert M. Vaughan, Bradley M. Dickson, Scott B. Rothbart
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
lysine methylation
reader domains
functional proteomics
non-histone proteins
lysine-orientated peptide libraries
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00241/full

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