Role of RelA-synthesized (p)ppGpp and ROS-induced mutagenesis in de novo acquisition of antibiotic resistance in E. coli

Role of RelA-synthesized (p)ppGpp and ROS-induced mutagenesis in de novo acquisition of antibiotic resistance in E. coli

Summary: The stringent response of bacteria to starvation and stress also fulfills a role in addressing the threat of antibiotics. Within this stringent response, (p)ppGpp, synthesized by RelA or SpoT, functions as a global alarmone. However, the effect of this (p)ppGpp on resistance development is...

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Bibliographic Details
Main Authors: Wenxi Qi, Martijs J. Jonker, Wim de Leeuw, Stanley Brul, Benno H. ter Kuile
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:iScience
Subjects:
Molecular biology
Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224008010

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