iNKT Cells Suppress Pathogenic NK1.1+CD8+ T Cells in DSS-Induced Colitis

iNKT Cells Suppress Pathogenic NK1.1+CD8+ T Cells in DSS-Induced Colitis

T cells producing IFNγ play a pathogenic role in the development of inflammatory bowel disease (IBD). To investigate the functions of CD1d-dependent invariant natural killer T (iNKT) cells in experimental colitis induced in Yeti mice with dysregulated expression of IFNγ, we generated iNKT cell-defic...

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Bibliographic Details
Main Authors: Sung Won Lee, Hyun Jung Park, Jae Hee Cheon, Lan Wu, Luc Van Kaer, Seokmann Hong
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
CD1d-dependent NKT cells
NK1.1+CD8+ T cells
Treg cells
IFNγ
DSS-induced colitis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02168/full

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