PML Nuclear bodies: the cancer connection and beyond
ABSTRACTPromyelocytic leukemia (PML) nuclear bodies, membrane-less organelles in the nucleus, play a crucial role in cellular homeostasis. These dynamic structures result from the assembly of scaffolding PML proteins and various partners. Recent crystal structure analyses revealed essential self-int...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
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| Series: | Nucleus |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19491034.2024.2321265 |
| _version_ | 1797293831113146368 |
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| author | Majdouline Abou-Ghali Valérie Lallemand-Breitenbach |
| author_facet | Majdouline Abou-Ghali Valérie Lallemand-Breitenbach |
| author_sort | Majdouline Abou-Ghali |
| collection | DOAJ |
| description | ABSTRACTPromyelocytic leukemia (PML) nuclear bodies, membrane-less organelles in the nucleus, play a crucial role in cellular homeostasis. These dynamic structures result from the assembly of scaffolding PML proteins and various partners. Recent crystal structure analyses revealed essential self-interacting domains, while liquid–liquid phase separation contributes to their formation. PML bodies orchestrate post-translational modifications, particularly stress-induced SUMOylation, impacting target protein functions. Serving as hubs in multiple signaling pathways, they influence cellular processes like senescence. Dysregulation of PML expression contributes to diseases, including cancer, highlighting their significance. Therapeutically, PML bodies are promising targets, exemplified by successful acute promyelocytic leukemia treatment with arsenic trioxide and retinoic acid restoring PML bodies. Understanding their functions illuminates both normal and pathological cellular physiology, guiding potential therapies. This review explores recent advancements in PML body biogenesis, biochemical activity, and their evolving biological roles. |
| first_indexed | 2024-03-07T21:21:32Z |
| format | Article |
| id | doaj.art-fc736dc7be794c4d825557f50abfb0e7 |
| institution | Directory Open Access Journal |
| issn | 1949-1034 1949-1042 |
| language | English |
| last_indexed | 2024-03-07T21:21:32Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Nucleus |
| spelling | doaj.art-fc736dc7be794c4d825557f50abfb0e72024-02-27T12:00:58ZengTaylor & Francis GroupNucleus1949-10341949-10422024-12-0115110.1080/19491034.2024.2321265PML Nuclear bodies: the cancer connection and beyondMajdouline Abou-Ghali0Valérie Lallemand-Breitenbach1Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, Université 11 PSL, Paris, FranceCenter for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, Université 11 PSL, Paris, FranceABSTRACTPromyelocytic leukemia (PML) nuclear bodies, membrane-less organelles in the nucleus, play a crucial role in cellular homeostasis. These dynamic structures result from the assembly of scaffolding PML proteins and various partners. Recent crystal structure analyses revealed essential self-interacting domains, while liquid–liquid phase separation contributes to their formation. PML bodies orchestrate post-translational modifications, particularly stress-induced SUMOylation, impacting target protein functions. Serving as hubs in multiple signaling pathways, they influence cellular processes like senescence. Dysregulation of PML expression contributes to diseases, including cancer, highlighting their significance. Therapeutically, PML bodies are promising targets, exemplified by successful acute promyelocytic leukemia treatment with arsenic trioxide and retinoic acid restoring PML bodies. Understanding their functions illuminates both normal and pathological cellular physiology, guiding potential therapies. This review explores recent advancements in PML body biogenesis, biochemical activity, and their evolving biological roles.https://www.tandfonline.com/doi/10.1080/19491034.2024.2321265Nuclear bodiesoxidative stressPMLpost-translational modificationssenescenceSUMO |
| spellingShingle | Majdouline Abou-Ghali Valérie Lallemand-Breitenbach PML Nuclear bodies: the cancer connection and beyond Nucleus Nuclear bodies oxidative stress PML post-translational modifications senescence SUMO |
| title | PML Nuclear bodies: the cancer connection and beyond |
| title_full | PML Nuclear bodies: the cancer connection and beyond |
| title_fullStr | PML Nuclear bodies: the cancer connection and beyond |
| title_full_unstemmed | PML Nuclear bodies: the cancer connection and beyond |
| title_short | PML Nuclear bodies: the cancer connection and beyond |
| title_sort | pml nuclear bodies the cancer connection and beyond |
| topic | Nuclear bodies oxidative stress PML post-translational modifications senescence SUMO |
| url | https://www.tandfonline.com/doi/10.1080/19491034.2024.2321265 |
| work_keys_str_mv | AT majdoulineaboughali pmlnuclearbodiesthecancerconnectionandbeyond AT valerielallemandbreitenbach pmlnuclearbodiesthecancerconnectionandbeyond |