Research Note: Improved feed efficiency in quail with targeted genome editing in the myostatin gene
ABSTRACT: Increased growth rate and decreased cost of feed are main focuses to increase revenue of poultry farms. Myostatin (MSTN) is a negative regulator of muscle growth and mutation on MSTN results in increased muscle growth. Due to the antimyogenic function of MSTN, MSTN gains high attention as...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | Poultry Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579121002911 |
| _version_ | 1819141961339109376 |
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| author | Joonbum Lee Dong-Hwan Kim Andrew M. Brower Izzy Schlachter Kichoon Lee |
| author_facet | Joonbum Lee Dong-Hwan Kim Andrew M. Brower Izzy Schlachter Kichoon Lee |
| author_sort | Joonbum Lee |
| collection | DOAJ |
| description | ABSTRACT: Increased growth rate and decreased cost of feed are main focuses to increase revenue of poultry farms. Myostatin (MSTN) is a negative regulator of muscle growth and mutation on MSTN results in increased muscle growth. Due to the antimyogenic function of MSTN, MSTN gains high attention as a potential target and genetic selection marker to increase meat yield in the livestock industry. In addition, MSTN can affect feed efficiencies and, thus decrease total feed requirement as shown in increased feed efficiencies in pigs and cattle with MSTN mutations. Although MSTN mutation in various animal species has been previously studied, MSTN mutation in avian species has only recently been generated to characterize its biological function. However, beneficial effects of MSTN mutation on poultry production need to be further investigated. In this study, using the MSTN mutant quail, feed efficiency related to interplay of changes in body weight gain (WG), feed intake (FI), and fat accretion were investigated. WG of mutant quail were significantly higher (P< 0.001) than those of wild-type (WT) from all time periods, 10-d interval from post-hatching day (D)10 to 40. Feed intake of mutant quail were significantly higher than those of WT from D 10 to 20 (P< 0.01) and D 20 to 30 (P< 0.001), but not from D 30 to 40, resulting in a significantly lower feed conversion ratio (FCR) of mutant quail compared to WT quail only from D 30 to 40 (P< 0.001). From those results, overall (D 10 to 40) FCR was significantly lower in mutant quail (P< 0.001) indicating improved feed efficiency by MSTN mutation. In addition, percentages of leg or abdominal fat compared to body weight in mutant quail at 8 wk were significantly lower than WT (P< 0.05). In combination to greater WG, less fat accretion might partially contribute to improved feed efficiency in MSTN mutant quail. As there is a current preference of meat with lower fat as a healthy food, MSTN can be used for the potential selection marker for not only bigger and leaner poultry, but also better feed efficiency that can satisfy both producers and consumers. |
| first_indexed | 2024-12-22T12:02:46Z |
| format | Article |
| id | doaj.art-fc73a133fc6f4b0fbdea14745df0aa35 |
| institution | Directory Open Access Journal |
| issn | 0032-5791 |
| language | English |
| last_indexed | 2024-12-22T12:02:46Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj.art-fc73a133fc6f4b0fbdea14745df0aa352022-12-21T18:26:32ZengElsevierPoultry Science0032-57912021-08-011008101257Research Note: Improved feed efficiency in quail with targeted genome editing in the myostatin geneJoonbum Lee0Dong-Hwan Kim1Andrew M. Brower2Izzy Schlachter3Kichoon Lee4Department of Animal Sciences, The Ohio State University, Columbus, OH 43210, USA; The Ohio State University Interdisciplinary Human Nutrition Program, The Ohio State University, Columbus, OH 43210, USADepartment of Animal Sciences, The Ohio State University, Columbus, OH 43210, USADepartment of Animal Sciences, The Ohio State University, Columbus, OH 43210, USADepartment of Animal Sciences, The Ohio State University, Columbus, OH 43210, USADepartment of Animal Sciences, The Ohio State University, Columbus, OH 43210, USA; The Ohio State University Interdisciplinary Human Nutrition Program, The Ohio State University, Columbus, OH 43210, USA; Corresponding author:ABSTRACT: Increased growth rate and decreased cost of feed are main focuses to increase revenue of poultry farms. Myostatin (MSTN) is a negative regulator of muscle growth and mutation on MSTN results in increased muscle growth. Due to the antimyogenic function of MSTN, MSTN gains high attention as a potential target and genetic selection marker to increase meat yield in the livestock industry. In addition, MSTN can affect feed efficiencies and, thus decrease total feed requirement as shown in increased feed efficiencies in pigs and cattle with MSTN mutations. Although MSTN mutation in various animal species has been previously studied, MSTN mutation in avian species has only recently been generated to characterize its biological function. However, beneficial effects of MSTN mutation on poultry production need to be further investigated. In this study, using the MSTN mutant quail, feed efficiency related to interplay of changes in body weight gain (WG), feed intake (FI), and fat accretion were investigated. WG of mutant quail were significantly higher (P< 0.001) than those of wild-type (WT) from all time periods, 10-d interval from post-hatching day (D)10 to 40. Feed intake of mutant quail were significantly higher than those of WT from D 10 to 20 (P< 0.01) and D 20 to 30 (P< 0.001), but not from D 30 to 40, resulting in a significantly lower feed conversion ratio (FCR) of mutant quail compared to WT quail only from D 30 to 40 (P< 0.001). From those results, overall (D 10 to 40) FCR was significantly lower in mutant quail (P< 0.001) indicating improved feed efficiency by MSTN mutation. In addition, percentages of leg or abdominal fat compared to body weight in mutant quail at 8 wk were significantly lower than WT (P< 0.05). In combination to greater WG, less fat accretion might partially contribute to improved feed efficiency in MSTN mutant quail. As there is a current preference of meat with lower fat as a healthy food, MSTN can be used for the potential selection marker for not only bigger and leaner poultry, but also better feed efficiency that can satisfy both producers and consumers.http://www.sciencedirect.com/science/article/pii/S0032579121002911myostatinfeed conversion ratioweight gainfat contentquail |
| spellingShingle | Joonbum Lee Dong-Hwan Kim Andrew M. Brower Izzy Schlachter Kichoon Lee Research Note: Improved feed efficiency in quail with targeted genome editing in the myostatin gene Poultry Science myostatin feed conversion ratio weight gain fat content quail |
| title | Research Note: Improved feed efficiency in quail with targeted genome editing in the myostatin gene |
| title_full | Research Note: Improved feed efficiency in quail with targeted genome editing in the myostatin gene |
| title_fullStr | Research Note: Improved feed efficiency in quail with targeted genome editing in the myostatin gene |
| title_full_unstemmed | Research Note: Improved feed efficiency in quail with targeted genome editing in the myostatin gene |
| title_short | Research Note: Improved feed efficiency in quail with targeted genome editing in the myostatin gene |
| title_sort | research note improved feed efficiency in quail with targeted genome editing in the myostatin gene |
| topic | myostatin feed conversion ratio weight gain fat content quail |
| url | http://www.sciencedirect.com/science/article/pii/S0032579121002911 |
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