Expression of the immune modulator secretory leukocyte protease inhibitor (SLPI) in colorectal cancer liver metastases and matched primary tumors is associated with a poorer prognosis
Secretory leukocyte protease inhibitor (SLPI), a pleiotropic protein expressed by healthy intestinal epithelial cells, functions as an inhibitor of NF-κB and neutrophil proteases and exerts antimicrobial activity. We previously showed SLPI suppresses intestinal epithelial chemokine production in res...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | OncoImmunology |
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| Online Access: | http://dx.doi.org/10.1080/2162402X.2020.1832761 |
| _version_ | 1818740442545520640 |
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| author | Sandrine Nugteren Jeroen A.C.M. Goos Pien M. Delis-van Diemen Ytje Simons-Oosterhuis Dicky J. Lindenbergh-Kortleve Daniëlle H. van Haaften Joyce Sanders Gerrit A. Meijer Remond J.A. Fijneman Janneke N. Samsom |
| author_facet | Sandrine Nugteren Jeroen A.C.M. Goos Pien M. Delis-van Diemen Ytje Simons-Oosterhuis Dicky J. Lindenbergh-Kortleve Daniëlle H. van Haaften Joyce Sanders Gerrit A. Meijer Remond J.A. Fijneman Janneke N. Samsom |
| author_sort | Sandrine Nugteren |
| collection | DOAJ |
| description | Secretory leukocyte protease inhibitor (SLPI), a pleiotropic protein expressed by healthy intestinal epithelial cells, functions as an inhibitor of NF-κB and neutrophil proteases and exerts antimicrobial activity. We previously showed SLPI suppresses intestinal epithelial chemokine production in response to microbial contact. Increased SLPI expression was recently detected in various types of carcinoma. In addition, accumulating evidence indicates SLPI expression is favorable for tumor cells. In view of these findings and the abundance of SLPI in the colonic epithelium, we hypothesized SLPI promotes colorectal cancer (CRC) growth and metastasis. Here, we aimed to establish whether SLPI expression in CRC is related to clinical outcome. Using a cohort of 507 patients with CRC who underwent resection of liver metastases, we show that high SLPI protein expression in both liver metastases and primary CRC is associated with significantly shorter overall survival after resection of liver metastases. The prognostic value of SLPI in CRC patients with liver metastases implies a role for SLPI in the formation of metastasis of human CRC. Based on the immune regulatory functions of SLPI, we anticipate that expression of SLPI provides tumors with a mechanism to evade infiltration by immune cells. |
| first_indexed | 2024-12-18T01:40:48Z |
| format | Article |
| id | doaj.art-fc76574b47aa47609bbe550ae5a8099c |
| institution | Directory Open Access Journal |
| issn | 2162-402X |
| language | English |
| last_indexed | 2024-12-18T01:40:48Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj.art-fc76574b47aa47609bbe550ae5a8099c2022-12-21T21:25:20ZengTaylor & Francis GroupOncoImmunology2162-402X2020-01-019110.1080/2162402X.2020.18327611832761Expression of the immune modulator secretory leukocyte protease inhibitor (SLPI) in colorectal cancer liver metastases and matched primary tumors is associated with a poorer prognosisSandrine Nugteren0Jeroen A.C.M. Goos1Pien M. Delis-van Diemen2Ytje Simons-Oosterhuis3Dicky J. Lindenbergh-Kortleve4Daniëlle H. van Haaften5Joyce Sanders6Gerrit A. Meijer7Remond J.A. Fijneman8Janneke N. Samsom9Erasmus University Medical CenterKarolinska InstituteThe Netherlands Cancer InstituteErasmus University Medical CenterErasmus University Medical CenterErasmus University Medical CenterThe Netherlands Cancer InstituteThe Netherlands Cancer InstituteThe Netherlands Cancer InstituteErasmus University Medical CenterSecretory leukocyte protease inhibitor (SLPI), a pleiotropic protein expressed by healthy intestinal epithelial cells, functions as an inhibitor of NF-κB and neutrophil proteases and exerts antimicrobial activity. We previously showed SLPI suppresses intestinal epithelial chemokine production in response to microbial contact. Increased SLPI expression was recently detected in various types of carcinoma. In addition, accumulating evidence indicates SLPI expression is favorable for tumor cells. In view of these findings and the abundance of SLPI in the colonic epithelium, we hypothesized SLPI promotes colorectal cancer (CRC) growth and metastasis. Here, we aimed to establish whether SLPI expression in CRC is related to clinical outcome. Using a cohort of 507 patients with CRC who underwent resection of liver metastases, we show that high SLPI protein expression in both liver metastases and primary CRC is associated with significantly shorter overall survival after resection of liver metastases. The prognostic value of SLPI in CRC patients with liver metastases implies a role for SLPI in the formation of metastasis of human CRC. Based on the immune regulatory functions of SLPI, we anticipate that expression of SLPI provides tumors with a mechanism to evade infiltration by immune cells.http://dx.doi.org/10.1080/2162402X.2020.1832761slpicolorectal cancerliver metastasesintestine |
| spellingShingle | Sandrine Nugteren Jeroen A.C.M. Goos Pien M. Delis-van Diemen Ytje Simons-Oosterhuis Dicky J. Lindenbergh-Kortleve Daniëlle H. van Haaften Joyce Sanders Gerrit A. Meijer Remond J.A. Fijneman Janneke N. Samsom Expression of the immune modulator secretory leukocyte protease inhibitor (SLPI) in colorectal cancer liver metastases and matched primary tumors is associated with a poorer prognosis OncoImmunology slpi colorectal cancer liver metastases intestine |
| title | Expression of the immune modulator secretory leukocyte protease inhibitor (SLPI) in colorectal cancer liver metastases and matched primary tumors is associated with a poorer prognosis |
| title_full | Expression of the immune modulator secretory leukocyte protease inhibitor (SLPI) in colorectal cancer liver metastases and matched primary tumors is associated with a poorer prognosis |
| title_fullStr | Expression of the immune modulator secretory leukocyte protease inhibitor (SLPI) in colorectal cancer liver metastases and matched primary tumors is associated with a poorer prognosis |
| title_full_unstemmed | Expression of the immune modulator secretory leukocyte protease inhibitor (SLPI) in colorectal cancer liver metastases and matched primary tumors is associated with a poorer prognosis |
| title_short | Expression of the immune modulator secretory leukocyte protease inhibitor (SLPI) in colorectal cancer liver metastases and matched primary tumors is associated with a poorer prognosis |
| title_sort | expression of the immune modulator secretory leukocyte protease inhibitor slpi in colorectal cancer liver metastases and matched primary tumors is associated with a poorer prognosis |
| topic | slpi colorectal cancer liver metastases intestine |
| url | http://dx.doi.org/10.1080/2162402X.2020.1832761 |
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