Inhibition of ERK downregulates autophagy via mitigating mitochondrial fragmentation to protect SH-SY5Y cells from OGD/R injury

Inhibition of ERK downregulates autophagy via mitigating mitochondrial fragmentation to protect SH-SY5Y cells from OGD/R injury

Abstract Background Cerebral ischemia-reperfusion injury (CIRI) is the main cause leading to high mortality and neurological disability in patients with cardiac arrest/cardiopulmonary resuscitation (CA/CPR). Our previous study found that extracellular signal-regulated kinase (ERK) activation, dynami...

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Bibliographic Details
Main Authors: Zhang-Li Yuan, Yan-Zi Mo, De-Li Li, Lu Xie, Meng-Hua Chen
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Cell Communication and Signaling
Subjects:
ERK
Drp1
Mfn2
Mitochondrial dynamics
Autophagy
OGD/R
Online Access:https://doi.org/10.1186/s12964-023-01211-3

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