JMJD3 in the regulation of human diseases
ABSTRACT In recent years, many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human diseases. The Jumonji domain-containing protein D3 (JMJD3), specifically demethylate di- and trimethyl-lysine 27 on histone H3 (H3...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2019-11-01
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| Series: | Protein & Cell |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s13238-019-0653-9 |
| _version_ | 1797706226525536256 |
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| author | Xiangxian Zhang Li Liu Xia Yuan Yuquan Wei Xiawei Wei |
| author_facet | Xiangxian Zhang Li Liu Xia Yuan Yuquan Wei Xiawei Wei |
| author_sort | Xiangxian Zhang |
| collection | DOAJ |
| description | ABSTRACT In recent years, many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human diseases. The Jumonji domain-containing protein D3 (JMJD3), specifically demethylate di- and trimethyl-lysine 27 on histone H3 (H3K27me2/3), has been widely studied in immune diseases, infectious diseases, cancer, developmental diseases, and aging related diseases. We will focus on the recent advances of JMJD3 function in human diseases, and looks ahead to the future of JMJD3 gene research in this review. |
| first_indexed | 2024-03-12T05:48:07Z |
| format | Article |
| id | doaj.art-fc79d06818ac4d59920cd37ea84f5172 |
| institution | Directory Open Access Journal |
| issn | 1674-800X 1674-8018 |
| language | English |
| last_indexed | 2024-03-12T05:48:07Z |
| publishDate | 2019-11-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Protein & Cell |
| spelling | doaj.art-fc79d06818ac4d59920cd37ea84f51722023-09-03T05:28:38ZengOxford University PressProtein & Cell1674-800X1674-80182019-11-01101286488210.1007/s13238-019-0653-9JMJD3 in the regulation of human diseasesXiangxian Zhang0Li Liu1Xia Yuan2Yuquan Wei3Xiawei Wei4Laboratory of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityLaboratory of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityLaboratory of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityLaboratory of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityLaboratory of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityABSTRACT In recent years, many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human diseases. The Jumonji domain-containing protein D3 (JMJD3), specifically demethylate di- and trimethyl-lysine 27 on histone H3 (H3K27me2/3), has been widely studied in immune diseases, infectious diseases, cancer, developmental diseases, and aging related diseases. We will focus on the recent advances of JMJD3 function in human diseases, and looks ahead to the future of JMJD3 gene research in this review.http://link.springer.com/article/10.1007/s13238-019-0653-9histone methylationJMJD3epigeneticshuman diseases |
| spellingShingle | Xiangxian Zhang Li Liu Xia Yuan Yuquan Wei Xiawei Wei JMJD3 in the regulation of human diseases Protein & Cell histone methylation JMJD3 epigenetics human diseases |
| title | JMJD3 in the regulation of human diseases |
| title_full | JMJD3 in the regulation of human diseases |
| title_fullStr | JMJD3 in the regulation of human diseases |
| title_full_unstemmed | JMJD3 in the regulation of human diseases |
| title_short | JMJD3 in the regulation of human diseases |
| title_sort | jmjd3 in the regulation of human diseases |
| topic | histone methylation JMJD3 epigenetics human diseases |
| url | http://link.springer.com/article/10.1007/s13238-019-0653-9 |
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