ISD3: a particokinetic model for predicting the combined effects of particle sedimentation, diffusion and dissolution on cellular dosimetry for in vitro systems

ISD3: a particokinetic model for predicting the combined effects of particle sedimentation, diffusion and dissolution on cellular dosimetry for in vitro systems

Abstract Background The development of particokinetic models describing the delivery of insoluble or poorly soluble nanoparticles to cells in liquid cell culture systems has improved the basis for dose-response analysis, hazard ranking from high-throughput systems, and now allows for translation of...

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Bibliographic Details
Main Authors: Dennis G. Thomas, Jordan N. Smith, Brian D. Thrall, Donald R. Baer, Hadley Jolley, Prabhakaran Munusamy, Vamsi Kodali, Philip Demokritou, Joel Cohen, Justin G. Teeguarden
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Particle and Fibre Toxicology
Subjects:
Nanoparticle
Dissolution
Population balance equation
Nanosilver
In vitro dosimetry
Particokinetic model
Online Access:http://link.springer.com/article/10.1186/s12989-018-0243-7

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