Histone H3K9 demethylase JMJD2B/KDM4B promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells by regulating H3K9me2 on RUNX2

Histone H3K9 demethylase JMJD2B/KDM4B promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells by regulating H3K9me2 on RUNX2

Background A variety of proteins including epigenetic factors are involved in the differentiation of human bone marrow mesenchymal stem cells. These cells also exhibited an epigenetic plasticity that enabled them to trans-differentiate from adipocytes to osteoblasts (and vice versa) after commitment...

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Bibliographic Details
Main Authors: Pan Kang, Zhiming Wu, Yuxi Huang, Zhen Luo, Shaochuan Huo, Qunqun Chen
Format: Article
Language:English
Published: PeerJ Inc. 2022-10-01
Series:PeerJ
Subjects:
Osteogenesis
JMJD2B
hBMSCs
Epigenetics
KDM4B
Online Access:https://peerj.com/articles/13862.pdf

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