Deciphering the potential ability of RG108 in cisplatin-induced HEI-OC1 ototoxicity: a research based on RNA-seq and molecular biology experiment

Deciphering the potential ability of RG108 in cisplatin-induced HEI-OC1 ototoxicity: a research based on RNA-seq and molecular biology experiment

Abstract Background Drug-induced hearing loss (DIHL) is very common, and seriously affects people's happiness in life. RG108 is a small molecule inhibitor. RG108 is protective against DIHL. Our purpose is to probe the incidence of RG108 on cisplatin-induced ototoxicity. Materials and methods In...

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Bibliographic Details
Main Authors: Dongdong Zhang, Yixin Sun, Min Lei, Yue Wang, Chengfu Cai
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Hereditas
Subjects:
Hearing loss
Ototoxicity
NRF2/PI3K-AKT axis
RG108
Online Access:https://doi.org/10.1186/s41065-023-00283-y

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