On the Rapid Calculation of Binding Affinities for Antigen and Antibody Design and Affinity Maturation Simulations

On the Rapid Calculation of Binding Affinities for Antigen and Antibody Design and Affinity Maturation Simulations

The accurate and efficient calculation of protein-protein binding affinities is an essential component in antibody and antigen design and optimization, and in computer modeling of antibody affinity maturation. Such calculations remain challenging despite advances in computer hardware and algorithms,...

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Bibliographic Details
Main Authors:	Simone Conti, Edmond Y. Lau, Victor Ovchinnikov
Format:	Article
Language:	English
Published:	MDPI AG 2022-08-01
Series:	Antibodies
Subjects:	molecular dynamics simulation free energy protein-protein interaction scoring function protein-protein docking
Online Access:	https://www.mdpi.com/2073-4468/11/3/51

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