Insights on the Dynamic Innovative Tumor Targeted-Nanoparticles-Based Drug Delivery Systems Activation Techniques
Nadia M Hamdy,1,* Georgette Eskander,2,* Emad B Basalious3,* 1Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt; 2Faculty of Pharmacy, Ain Shams University, Postgraduate Student, Cairo, Egypt; 3Department of Pharmaceutics and Industrial P...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-12-01
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| Series: | International Journal of Nanomedicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/insights-on-the-dynamic-innovative-tumor-targeted-nanoparticles-based--peer-reviewed-fulltext-article-IJN |
| _version_ | 1811184304736174080 |
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| author | Hamdy NM Eskander G Basalious EB |
| author_facet | Hamdy NM Eskander G Basalious EB |
| author_sort | Hamdy NM |
| collection | DOAJ |
| description | Nadia M Hamdy,1,* Georgette Eskander,2,* Emad B Basalious3,* 1Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt; 2Faculty of Pharmacy, Ain Shams University, Postgraduate Student, Cairo, Egypt; 3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt*These authors contributed equally to this workCorrespondence: Emad B Basalious; Nadia M Hamdy, Email Emad.basalious@pharma.cu.edu.eg; nadia_hamdy@pharma.asu.edu.egAbstract: Anti-cancer conventional chemotherapeutic drugs novel formula progress, nowadays, uses nano technology for targeted drug delivery, specifically tailored to overcome therapeutic agents’ delivery challenges. Polymer drug delivery systems (DDS) play a crucial role in minimizing off-target side effects arising when using standard cytotoxic drugs. Using nano-formula for targeted localized action, permits using larger effective cytotoxic doses on a single special spot, that can seriously cause harm if it was administered systemically. Therefore, various nanoparticles (NPs) specifically have attached groups for targeting capabilities, not seen in bulk materials, which then need activation. In this review, we will present a simple innovative, illustrative, in a cartoon-way, enumeration of NP anti-cancer drug targeting delivery system activation-types. Area(s) covered in this review are the mechanisms of various NP activation techniques.Graphical Abstract: Keywords: intrinsic-activation, extrinsic-activation, NPs, nanoparticles, DDS, drug delivery systems, cancer biology, nano-bio-medicine |
| first_indexed | 2024-04-11T13:09:57Z |
| format | Article |
| id | doaj.art-fc8026580d504a18826490653eed12b6 |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-04-11T13:09:57Z |
| publishDate | 2022-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-fc8026580d504a18826490653eed12b62022-12-22T04:22:37ZengDove Medical PressInternational Journal of Nanomedicine1178-20132022-12-01Volume 176131615580177Insights on the Dynamic Innovative Tumor Targeted-Nanoparticles-Based Drug Delivery Systems Activation TechniquesHamdy NMEskander GBasalious EBNadia M Hamdy,1,* Georgette Eskander,2,* Emad B Basalious3,* 1Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt; 2Faculty of Pharmacy, Ain Shams University, Postgraduate Student, Cairo, Egypt; 3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt*These authors contributed equally to this workCorrespondence: Emad B Basalious; Nadia M Hamdy, Email Emad.basalious@pharma.cu.edu.eg; nadia_hamdy@pharma.asu.edu.egAbstract: Anti-cancer conventional chemotherapeutic drugs novel formula progress, nowadays, uses nano technology for targeted drug delivery, specifically tailored to overcome therapeutic agents’ delivery challenges. Polymer drug delivery systems (DDS) play a crucial role in minimizing off-target side effects arising when using standard cytotoxic drugs. Using nano-formula for targeted localized action, permits using larger effective cytotoxic doses on a single special spot, that can seriously cause harm if it was administered systemically. Therefore, various nanoparticles (NPs) specifically have attached groups for targeting capabilities, not seen in bulk materials, which then need activation. In this review, we will present a simple innovative, illustrative, in a cartoon-way, enumeration of NP anti-cancer drug targeting delivery system activation-types. Area(s) covered in this review are the mechanisms of various NP activation techniques.Graphical Abstract: Keywords: intrinsic-activation, extrinsic-activation, NPs, nanoparticles, DDS, drug delivery systems, cancer biology, nano-bio-medicinehttps://www.dovepress.com/insights-on-the-dynamic-innovative-tumor-targeted-nanoparticles-based--peer-reviewed-fulltext-article-IJNintrinsic-activationextrinsic-activationnpsnanoparticlesddsdrug delivery systemscancer biologynano-biomedicine |
| spellingShingle | Hamdy NM Eskander G Basalious EB Insights on the Dynamic Innovative Tumor Targeted-Nanoparticles-Based Drug Delivery Systems Activation Techniques International Journal of Nanomedicine intrinsic-activation extrinsic-activation nps nanoparticles dds drug delivery systems cancer biology nano-biomedicine |
| title | Insights on the Dynamic Innovative Tumor Targeted-Nanoparticles-Based Drug Delivery Systems Activation Techniques |
| title_full | Insights on the Dynamic Innovative Tumor Targeted-Nanoparticles-Based Drug Delivery Systems Activation Techniques |
| title_fullStr | Insights on the Dynamic Innovative Tumor Targeted-Nanoparticles-Based Drug Delivery Systems Activation Techniques |
| title_full_unstemmed | Insights on the Dynamic Innovative Tumor Targeted-Nanoparticles-Based Drug Delivery Systems Activation Techniques |
| title_short | Insights on the Dynamic Innovative Tumor Targeted-Nanoparticles-Based Drug Delivery Systems Activation Techniques |
| title_sort | insights on the dynamic innovative tumor targeted nanoparticles based drug delivery systems activation techniques |
| topic | intrinsic-activation extrinsic-activation nps nanoparticles dds drug delivery systems cancer biology nano-biomedicine |
| url | https://www.dovepress.com/insights-on-the-dynamic-innovative-tumor-targeted-nanoparticles-based--peer-reviewed-fulltext-article-IJN |
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