Development and validation of the Vanderbilt PRS-KS, an instrument to quantify polygenic risk score knowledge
Purpose: As polygenic risk scores (PRSs) enter clinical practice, health care providers’ and the publics’ comprehension of PRS results are of great importance; yet, they are poorly understood. We present the Vanderbilt polygenic risk scores knowledge scale (Vanderbilt PRS-KS), a tool to quantify PRS...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Genetics in Medicine Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949774423008312 |
| _version_ | 1797341935606693888 |
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| author | Doug Stubbs Gillian W. Hooker Yajing Li Lucas Richter Alexander Bick |
| author_facet | Doug Stubbs Gillian W. Hooker Yajing Li Lucas Richter Alexander Bick |
| author_sort | Doug Stubbs |
| collection | DOAJ |
| description | Purpose: As polygenic risk scores (PRSs) enter clinical practice, health care providers’ and the publics’ comprehension of PRS results are of great importance; yet, they are poorly understood. We present the Vanderbilt polygenic risk scores knowledge scale (Vanderbilt PRS-KS), a tool to quantify PRS knowledge. Methods: The Vanderbilt PRS-KS was developed by a team of genetic counselors and physicians to cover key conceptual facts pertaining to PRSs. We recruited (n = 500) individuals with demographics representative of a U.S. sample and graduate-level health care students (n = 74) at a large academic medical center to participate in this validation study. We evaluated the Vanderbilt PRS-KS’s psychometric properties using confirmatory factor analysis and item response theory. Results: The 7-item Vanderbilt PRS-KS correlated to a single latent construct on confirmatory factor analysis (Λ = 0.31-0.61). The scale showed promising reliability (Cronbach’s α = 0.66) with item response theory summed scores of ≥2 to ≤5, demonstrating reliability >0.70. The Vanderbilt PRS-KS significantly correlated with genetic knowledge and applied PRS knowledge (r = 0.55 and r = 0.29), and graduate-level health care students scored significantly higher compared with the U.S. representative sample (P < .01). Conclusion: The Vanderbilt PRS-KS is a rigorously validated measure to quantify PRS knowledge. Clinicians should tailor future PRS knowledge interventions to the identified knowledge gaps, including PRS inheritance, equity of performance in different ethnicities, and integration with other health determinants. |
| first_indexed | 2024-03-08T10:26:11Z |
| format | Article |
| id | doaj.art-fc808c84733843f585f46ecbc45def17 |
| institution | Directory Open Access Journal |
| issn | 2949-7744 |
| language | English |
| last_indexed | 2024-03-08T10:26:11Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Genetics in Medicine Open |
| spelling | doaj.art-fc808c84733843f585f46ecbc45def172024-01-27T07:13:37ZengElsevierGenetics in Medicine Open2949-77442023-01-0111100822Development and validation of the Vanderbilt PRS-KS, an instrument to quantify polygenic risk score knowledgeDoug Stubbs0Gillian W. Hooker1Yajing Li2Lucas Richter3Alexander Bick4Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN; Correspondence and requests for materials should be addressed to Doug Stubbs, Vanderbilt University Medical Center, Vanderbilt Genetics Institute, RRB-550, 2200 Pierce Ave, Nashville, TN 37232.Concert Genetics, Nashville, TN; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TNDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TNDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TNDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TNPurpose: As polygenic risk scores (PRSs) enter clinical practice, health care providers’ and the publics’ comprehension of PRS results are of great importance; yet, they are poorly understood. We present the Vanderbilt polygenic risk scores knowledge scale (Vanderbilt PRS-KS), a tool to quantify PRS knowledge. Methods: The Vanderbilt PRS-KS was developed by a team of genetic counselors and physicians to cover key conceptual facts pertaining to PRSs. We recruited (n = 500) individuals with demographics representative of a U.S. sample and graduate-level health care students (n = 74) at a large academic medical center to participate in this validation study. We evaluated the Vanderbilt PRS-KS’s psychometric properties using confirmatory factor analysis and item response theory. Results: The 7-item Vanderbilt PRS-KS correlated to a single latent construct on confirmatory factor analysis (Λ = 0.31-0.61). The scale showed promising reliability (Cronbach’s α = 0.66) with item response theory summed scores of ≥2 to ≤5, demonstrating reliability >0.70. The Vanderbilt PRS-KS significantly correlated with genetic knowledge and applied PRS knowledge (r = 0.55 and r = 0.29), and graduate-level health care students scored significantly higher compared with the U.S. representative sample (P < .01). Conclusion: The Vanderbilt PRS-KS is a rigorously validated measure to quantify PRS knowledge. Clinicians should tailor future PRS knowledge interventions to the identified knowledge gaps, including PRS inheritance, equity of performance in different ethnicities, and integration with other health determinants.http://www.sciencedirect.com/science/article/pii/S2949774423008312Polygenic risk scoreGenetic knowledgeGenomic risk scoreKnowledge scaleScale validation |
| spellingShingle | Doug Stubbs Gillian W. Hooker Yajing Li Lucas Richter Alexander Bick Development and validation of the Vanderbilt PRS-KS, an instrument to quantify polygenic risk score knowledge Genetics in Medicine Open Polygenic risk score Genetic knowledge Genomic risk score Knowledge scale Scale validation |
| title | Development and validation of the Vanderbilt PRS-KS, an instrument to quantify polygenic risk score knowledge |
| title_full | Development and validation of the Vanderbilt PRS-KS, an instrument to quantify polygenic risk score knowledge |
| title_fullStr | Development and validation of the Vanderbilt PRS-KS, an instrument to quantify polygenic risk score knowledge |
| title_full_unstemmed | Development and validation of the Vanderbilt PRS-KS, an instrument to quantify polygenic risk score knowledge |
| title_short | Development and validation of the Vanderbilt PRS-KS, an instrument to quantify polygenic risk score knowledge |
| title_sort | development and validation of the vanderbilt prs ks an instrument to quantify polygenic risk score knowledge |
| topic | Polygenic risk score Genetic knowledge Genomic risk score Knowledge scale Scale validation |
| url | http://www.sciencedirect.com/science/article/pii/S2949774423008312 |
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