Stability, Permeability and Cytotoxicity of Buccal Films in Allergy Treatment
Oral mucoadhesive systems, such as polymer films, are among innovative pharmaceutical products. These systems can be applied in swallowing problems and can also be used in geriatrics and paediatrics. In our earlier work, we successfully formulated buccal mucoadhesive polymer films, which contained c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/8/1633 |
| _version_ | 1797442813485383680 |
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| author | Krisztián Pamlényi Géza Regdon Dániel Nemes Ferenc Fenyvesi Ildikó Bácskay Katalin Kristó |
| author_facet | Krisztián Pamlényi Géza Regdon Dániel Nemes Ferenc Fenyvesi Ildikó Bácskay Katalin Kristó |
| author_sort | Krisztián Pamlényi |
| collection | DOAJ |
| description | Oral mucoadhesive systems, such as polymer films, are among innovative pharmaceutical products. These systems can be applied in swallowing problems and can also be used in geriatrics and paediatrics. In our earlier work, we successfully formulated buccal mucoadhesive polymer films, which contained cetirizine-hydrochloride (CTZ) as the API. The present study focused on investigating the stability and permeability of the prepared films. The stability of the films was studied with an accelerated stability test. During the stability test, thickness, breaking hardness and in vitro mucoadhesivity were analysed. Furthermore, the interactions were studied with FT-IR spectroscopy, and the changes in the amount of the API were also monitored. Cytotoxicity and cell line permeability studies were carried out on TR 146 buccal cells. Compositions that can preserve more than 85% of the API after 6 months were found. Most of the compositions had a high cell viability of more than 50%. Citric acid (CA) decreased the stability and reduced every physical parameter of the films. However, cell line studies showed that the permeability of the films was enhanced. In our work, we successfully formulated CTZ-containing buccal films with adequate stability, high cell viability and appropriate absorption properties. |
| first_indexed | 2024-03-09T12:47:31Z |
| format | Article |
| id | doaj.art-fc839fa2c1114ba88696d5a70760008e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T12:47:31Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-fc839fa2c1114ba88696d5a70760008e2023-11-30T22:11:33ZengMDPI AGPharmaceutics1999-49232022-08-01148163310.3390/pharmaceutics14081633Stability, Permeability and Cytotoxicity of Buccal Films in Allergy TreatmentKrisztián Pamlényi0Géza Regdon1Dániel Nemes2Ferenc Fenyvesi3Ildikó Bácskay4Katalin Kristó5Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, H-6720 Szeged, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, H-6720 Szeged, HungaryDepartment of Pharmaceutical Technology, University of Debrecen, H-4032 Debrecen, HungaryDepartment of Pharmaceutical Technology, University of Debrecen, H-4032 Debrecen, HungaryDepartment of Pharmaceutical Technology, University of Debrecen, H-4032 Debrecen, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, H-6720 Szeged, HungaryOral mucoadhesive systems, such as polymer films, are among innovative pharmaceutical products. These systems can be applied in swallowing problems and can also be used in geriatrics and paediatrics. In our earlier work, we successfully formulated buccal mucoadhesive polymer films, which contained cetirizine-hydrochloride (CTZ) as the API. The present study focused on investigating the stability and permeability of the prepared films. The stability of the films was studied with an accelerated stability test. During the stability test, thickness, breaking hardness and in vitro mucoadhesivity were analysed. Furthermore, the interactions were studied with FT-IR spectroscopy, and the changes in the amount of the API were also monitored. Cytotoxicity and cell line permeability studies were carried out on TR 146 buccal cells. Compositions that can preserve more than 85% of the API after 6 months were found. Most of the compositions had a high cell viability of more than 50%. Citric acid (CA) decreased the stability and reduced every physical parameter of the films. However, cell line studies showed that the permeability of the films was enhanced. In our work, we successfully formulated CTZ-containing buccal films with adequate stability, high cell viability and appropriate absorption properties.https://www.mdpi.com/1999-4923/14/8/1633mucoadhesivebuccal filmsdrug deliveryalginatecetirizineantihistamine |
| spellingShingle | Krisztián Pamlényi Géza Regdon Dániel Nemes Ferenc Fenyvesi Ildikó Bácskay Katalin Kristó Stability, Permeability and Cytotoxicity of Buccal Films in Allergy Treatment Pharmaceutics mucoadhesive buccal films drug delivery alginate cetirizine antihistamine |
| title | Stability, Permeability and Cytotoxicity of Buccal Films in Allergy Treatment |
| title_full | Stability, Permeability and Cytotoxicity of Buccal Films in Allergy Treatment |
| title_fullStr | Stability, Permeability and Cytotoxicity of Buccal Films in Allergy Treatment |
| title_full_unstemmed | Stability, Permeability and Cytotoxicity of Buccal Films in Allergy Treatment |
| title_short | Stability, Permeability and Cytotoxicity of Buccal Films in Allergy Treatment |
| title_sort | stability permeability and cytotoxicity of buccal films in allergy treatment |
| topic | mucoadhesive buccal films drug delivery alginate cetirizine antihistamine |
| url | https://www.mdpi.com/1999-4923/14/8/1633 |
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