Changes in the mammary gland during aging and its links with breast diseases
The functional capacity of organisms declines in the process of aging. In the case of breast tissue, abnormal mammary gland development can lead to dysfunction in milk secretion, a primary function, as well as the onset of various diseases, such as breast cancer. In the process of aging, the termina...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
China Science Publishing & Media Ltd.
2023-05-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2023073 |
| _version_ | 1827769569345798144 |
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| author | Lin Junqiang Ye Shihui Ke Hao Lin Liang Wu Xia Guo Mengfei Jiao Baowei Chen Ceshi Zhao Limin |
| author_facet | Lin Junqiang Ye Shihui Ke Hao Lin Liang Wu Xia Guo Mengfei Jiao Baowei Chen Ceshi Zhao Limin |
| author_sort | Lin Junqiang |
| collection | DOAJ |
| description | The functional capacity of organisms declines in the process of aging. In the case of breast tissue, abnormal mammary gland development can lead to dysfunction in milk secretion, a primary function, as well as the onset of various diseases, such as breast cancer. In the process of aging, the terminal duct lobular units (TDLUs) within the breast undergo gradual degeneration, while the proportion of adipose tissue in the breast continues to increase and hormonal levels in the breast change accordingly. Here, we review changes in morphology, internal structure, and cellular composition that occur in the mammary gland during aging. We also explore the emerging mechanisms of breast aging and the relationship between changes during aging and breast-related diseases, as well as potential interventions for delaying mammary gland aging and preventing breast disease. |
| first_indexed | 2024-03-11T12:27:14Z |
| format | Article |
| id | doaj.art-fc83c49755114b06aeb086515267a964 |
| institution | Directory Open Access Journal |
| issn | 1672-9145 |
| language | English |
| last_indexed | 2024-03-11T12:27:14Z |
| publishDate | 2023-05-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj.art-fc83c49755114b06aeb086515267a9642023-11-06T08:40:16ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452023-05-01551001101910.3724/abbs.202307320d259ccChanges in the mammary gland during aging and its links with breast diseasesLin Junqiang0Ye Shihui1Ke Hao2Lin Liang3Wu Xia4Guo Mengfei5Jiao Baowei6Chen Ceshi7Zhao Limin8["Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, and Jiangxi Key Laboratory of Human Aging, Nanchang 330031, China"]["Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, and Jiangxi Key Laboratory of Human Aging, Nanchang 330031, China"]["Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, and Jiangxi Key Laboratory of Human Aging, Nanchang 330031, China"]["Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, and Jiangxi Key Laboratory of Human Aging, Nanchang 330031, China"]["Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, and Jiangxi Key Laboratory of Human Aging, Nanchang 330031, China"]["Huankui Academy, Nanchang University, Nanchang 330031, China"]["State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China","KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China"]["Academy of Biomedical Engineering, Kunming Medical University, Kunming 650500, China","Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China","The Third Affiliated Hospital, Kunming Medical University, Kunming 650118, China"]["Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, and Jiangxi Key Laboratory of Human Aging, Nanchang 330031, China"]The functional capacity of organisms declines in the process of aging. In the case of breast tissue, abnormal mammary gland development can lead to dysfunction in milk secretion, a primary function, as well as the onset of various diseases, such as breast cancer. In the process of aging, the terminal duct lobular units (TDLUs) within the breast undergo gradual degeneration, while the proportion of adipose tissue in the breast continues to increase and hormonal levels in the breast change accordingly. Here, we review changes in morphology, internal structure, and cellular composition that occur in the mammary gland during aging. We also explore the emerging mechanisms of breast aging and the relationship between changes during aging and breast-related diseases, as well as potential interventions for delaying mammary gland aging and preventing breast disease.https://www.sciengine.com/doi/10.3724/abbs.2023073agingmammary glandbreast diseasebreast cancer |
| spellingShingle | Lin Junqiang Ye Shihui Ke Hao Lin Liang Wu Xia Guo Mengfei Jiao Baowei Chen Ceshi Zhao Limin Changes in the mammary gland during aging and its links with breast diseases Acta Biochimica et Biophysica Sinica aging mammary gland breast disease breast cancer |
| title | Changes in the mammary gland during aging and its links with breast diseases |
| title_full | Changes in the mammary gland during aging and its links with breast diseases |
| title_fullStr | Changes in the mammary gland during aging and its links with breast diseases |
| title_full_unstemmed | Changes in the mammary gland during aging and its links with breast diseases |
| title_short | Changes in the mammary gland during aging and its links with breast diseases |
| title_sort | changes in the mammary gland during aging and its links with breast diseases |
| topic | aging mammary gland breast disease breast cancer |
| url | https://www.sciengine.com/doi/10.3724/abbs.2023073 |
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