Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq

Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq

Phage immunoprecipitation sequencing (PhIP-seq) allows for unbiased, proteome-wide autoantibody discovery across a variety of disease settings, with identification of disease-specific autoantigens providing new insight into previously poorly understood forms of immune dysregulation. Despite several...

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Bibliographic Details
Main Authors: Sara E Vazquez, Sabrina A Mann, Aaron Bodansky, Andrew F Kung, Zoe Quandt, Elise MN Ferré, Nils Landegren, Daniel Eriksson, Paul Bastard, Shen-Ying Zhang, Jamin Liu, Anthea Mitchell, Irina Proekt, David Yu, Caleigh Mandel-Brehm, Chung-Yu Wang, Brenda Miao, Gavin Sowa, Kelsey Zorn, Alice Y Chan, Veronica M Tagi, Chisato Shimizu, Adriana Tremoulet, Kara Lynch, Michael R Wilson, Olle Kämpe, Kerry Dobbs, Ottavia M Delmonte, Rosa Bacchetta, Luigi D Notarangelo, Jane C Burns, Jean-Laurent Casanova, Michail S Lionakis, Troy R Torgerson, Mark S Anderson, Joseph L DeRisi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-10-01
Series:eLife
Subjects:
PhIP-seq
autoantibody
autoantigen
COVID-19
APS1
IPEX
Online Access:https://elifesciences.org/articles/78550

Internet

https://elifesciences.org/articles/78550

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