Volume transmission and receptor-receptor interactions in heteroreceptor complexes: understanding the role of new concepts for brain communication
The discovery of the central monoamine neurons not only demonstrated novel types of brain stem neurons forming global terminal networks all over the brain and the spinal cord, but also to a novel type of communication called volume transmission. It is a major mode of communication in the central ner...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=8;spage=1220;epage=1223;aulast=Fuxe |
| _version_ | 1818305897410068480 |
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| author | Kjell Fuxe Dasiel O Borroto-Escuela |
| author_facet | Kjell Fuxe Dasiel O Borroto-Escuela |
| author_sort | Kjell Fuxe |
| collection | DOAJ |
| description | The discovery of the central monoamine neurons not only demonstrated novel types of brain stem neurons forming global terminal networks all over the brain and the spinal cord, but also to a novel type of communication called volume transmission. It is a major mode of communication in the central nervous system that takes places in the extracellular fluid and the cerebral spinal fluid through diffusion and flow of molecules, like neurotransmitters and extracellular vesicles. The integration of synaptic and volume transmission takes place through allosteric receptor-receptor interactions in heteroreceptor complexes. These heterocomplexes represent major integrator centres in the plasma membrane and their protomers act as moonlighting proteins undergoing dynamic changes and their structure and function. In fact, we propose that the molecular bases of learning and memory can be based on the reorganization of multiples homo and heteroreceptor complexes into novel assembles in the post-junctional membranes of synapses. |
| first_indexed | 2024-12-13T06:33:53Z |
| format | Article |
| id | doaj.art-fc84ddd9d7be4706b13d3193330eaf93 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-13T06:33:53Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-fc84ddd9d7be4706b13d3193330eaf932022-12-21T23:56:33ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742016-01-011181220122310.4103/1673-5374.189168Volume transmission and receptor-receptor interactions in heteroreceptor complexes: understanding the role of new concepts for brain communicationKjell FuxeDasiel O Borroto-EscuelaThe discovery of the central monoamine neurons not only demonstrated novel types of brain stem neurons forming global terminal networks all over the brain and the spinal cord, but also to a novel type of communication called volume transmission. It is a major mode of communication in the central nervous system that takes places in the extracellular fluid and the cerebral spinal fluid through diffusion and flow of molecules, like neurotransmitters and extracellular vesicles. The integration of synaptic and volume transmission takes place through allosteric receptor-receptor interactions in heteroreceptor complexes. These heterocomplexes represent major integrator centres in the plasma membrane and their protomers act as moonlighting proteins undergoing dynamic changes and their structure and function. In fact, we propose that the molecular bases of learning and memory can be based on the reorganization of multiples homo and heteroreceptor complexes into novel assembles in the post-junctional membranes of synapses.http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=8;spage=1220;epage=1223;aulast=Fuxevolume transmission; receptor-receptor interaction; heteroreceptor complexes; oligomerization; brain communication; learning; memory; central monoamine neurons |
| spellingShingle | Kjell Fuxe Dasiel O Borroto-Escuela Volume transmission and receptor-receptor interactions in heteroreceptor complexes: understanding the role of new concepts for brain communication Neural Regeneration Research volume transmission; receptor-receptor interaction; heteroreceptor complexes; oligomerization; brain communication; learning; memory; central monoamine neurons |
| title | Volume transmission and receptor-receptor interactions in heteroreceptor complexes: understanding the role of new concepts for brain communication |
| title_full | Volume transmission and receptor-receptor interactions in heteroreceptor complexes: understanding the role of new concepts for brain communication |
| title_fullStr | Volume transmission and receptor-receptor interactions in heteroreceptor complexes: understanding the role of new concepts for brain communication |
| title_full_unstemmed | Volume transmission and receptor-receptor interactions in heteroreceptor complexes: understanding the role of new concepts for brain communication |
| title_short | Volume transmission and receptor-receptor interactions in heteroreceptor complexes: understanding the role of new concepts for brain communication |
| title_sort | volume transmission and receptor receptor interactions in heteroreceptor complexes understanding the role of new concepts for brain communication |
| topic | volume transmission; receptor-receptor interaction; heteroreceptor complexes; oligomerization; brain communication; learning; memory; central monoamine neurons |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=8;spage=1220;epage=1223;aulast=Fuxe |
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