Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31

Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31

Abstract Background Genome-wide association studies (GWAS) have uncovered many genetic risk loci for psoriasis, yet many remain uncharacterised in terms of the causal gene and their biological mechanism in disease. This is largely a result of the findings that over 90% of GWAS variants map outside o...

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Bibliographic Details
Main Authors: Helen Ray-Jones, Kate Duffus, Amanda McGovern, Paul Martin, Chenfu Shi, Jenny Hankinson, Oliver Gough, Annie Yarwood, Andrew P. Morris, Antony Adamson, Christopher Taylor, James Ding, Vasanthi Priyadarshini Gaddi, Yao Fu, Patrick Gaffney, Gisela Orozco, Richard B. Warren, Steve Eyre
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Biology
Subjects:
Psoriasis
Chromatin
GWAS
CHi-C
HiChIP
CRISPR
Online Access:http://link.springer.com/article/10.1186/s12915-020-00779-3

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