Medical devices as a source of phthalate exposure: a review of current knowledge and alternative solutions
Phthalates are a group of phthalic acid esters used as plasticisers in a large number of products to improve their flexibility, softness, and extensibility. Their wide use in medical devices, however, raises a lot of concern, as they can enter the organism and have toxic effects on human liver, thyr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2022-09-01
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| Series: | Arhiv za Higijenu Rada i Toksikologiju |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/aiht-2022-73-3639 |
| _version_ | 1811332798045224960 |
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| author | Šimunović Antonela Tomić Siniša Kranjčec Krunoslav |
| author_facet | Šimunović Antonela Tomić Siniša Kranjčec Krunoslav |
| author_sort | Šimunović Antonela |
| collection | DOAJ |
| description | Phthalates are a group of phthalic acid esters used as plasticisers in a large number of products to improve their flexibility, softness, and extensibility. Their wide use in medical devices, however, raises a lot of concern, as they can enter the organism and have toxic effects on human liver, thyroid, kidneys, lungs, reproductive, endocrine, nervous, and respiratory system and are associated with asthma, obesity, autism, and diabetes. The aim of this review is to summarise current knowledge about phthalate migration from medical devices during different medical procedures and possible impact on patient health. It also looks at alternative plasticisers with supposedly lower migration rates and safer profile. Not enough is known about which and how many phthalates make part of medical devices or about the health impacts of alternative plasticisers or their migration rates. |
| first_indexed | 2024-04-13T16:42:22Z |
| format | Article |
| id | doaj.art-fc884df3a38441fd8a33cbd87c216f0d |
| institution | Directory Open Access Journal |
| issn | 1848-6312 |
| language | English |
| last_indexed | 2024-04-13T16:42:22Z |
| publishDate | 2022-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Arhiv za Higijenu Rada i Toksikologiju |
| spelling | doaj.art-fc884df3a38441fd8a33cbd87c216f0d2022-12-22T02:39:12ZengSciendoArhiv za Higijenu Rada i Toksikologiju1848-63122022-09-0173317919010.2478/aiht-2022-73-3639Medical devices as a source of phthalate exposure: a review of current knowledge and alternative solutionsŠimunović Antonela0Tomić Siniša1Kranjčec Krunoslav2Croatian Agency for Medicinal Products and Medical Devices, Zagreb, CroatiaCroatian Agency for Medicinal Products and Medical Devices, Zagreb, CroatiaCroatian Agency for Medicinal Products and Medical Devices, Zagreb, CroatiaPhthalates are a group of phthalic acid esters used as plasticisers in a large number of products to improve their flexibility, softness, and extensibility. Their wide use in medical devices, however, raises a lot of concern, as they can enter the organism and have toxic effects on human liver, thyroid, kidneys, lungs, reproductive, endocrine, nervous, and respiratory system and are associated with asthma, obesity, autism, and diabetes. The aim of this review is to summarise current knowledge about phthalate migration from medical devices during different medical procedures and possible impact on patient health. It also looks at alternative plasticisers with supposedly lower migration rates and safer profile. Not enough is known about which and how many phthalates make part of medical devices or about the health impacts of alternative plasticisers or their migration rates.https://doi.org/10.2478/aiht-2022-73-3639plasticisershuman exposureregulationreproductive system disorderstoxicologyljudska izloženostplastifikatoriporemećaj reproduktivnog sustavatoksikologijazakonska regulativa |
| spellingShingle | Šimunović Antonela Tomić Siniša Kranjčec Krunoslav Medical devices as a source of phthalate exposure: a review of current knowledge and alternative solutions Arhiv za Higijenu Rada i Toksikologiju plasticisers human exposure regulation reproductive system disorders toxicology ljudska izloženost plastifikatori poremećaj reproduktivnog sustava toksikologija zakonska regulativa |
| title | Medical devices as a source of phthalate exposure: a review of current knowledge and alternative solutions |
| title_full | Medical devices as a source of phthalate exposure: a review of current knowledge and alternative solutions |
| title_fullStr | Medical devices as a source of phthalate exposure: a review of current knowledge and alternative solutions |
| title_full_unstemmed | Medical devices as a source of phthalate exposure: a review of current knowledge and alternative solutions |
| title_short | Medical devices as a source of phthalate exposure: a review of current knowledge and alternative solutions |
| title_sort | medical devices as a source of phthalate exposure a review of current knowledge and alternative solutions |
| topic | plasticisers human exposure regulation reproductive system disorders toxicology ljudska izloženost plastifikatori poremećaj reproduktivnog sustava toksikologija zakonska regulativa |
| url | https://doi.org/10.2478/aiht-2022-73-3639 |
| work_keys_str_mv | AT simunovicantonela medicaldevicesasasourceofphthalateexposureareviewofcurrentknowledgeandalternativesolutions AT tomicsinisa medicaldevicesasasourceofphthalateexposureareviewofcurrentknowledgeandalternativesolutions AT kranjceckrunoslav medicaldevicesasasourceofphthalateexposureareviewofcurrentknowledgeandalternativesolutions |