Triphenylphosphonium Modified Mesoporous Silica Nanoparticle for Enhanced Algicidal Efficacy of Cyclohexyl-(3,4-dichlorobenzyl) Amine
Mesoporous silica nanoparticles (MSNPs) have been widely used for the delivery of different hydrophilic and hydrophobic drugs owing to their large surface area and ease of chemical alteration. On the other hand, triphenylphosphonium cation (TPP+) with high lipophilicity has a great mitochondrial hom...
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/19/11901 |
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| author | Ho-Joong Kim Sung Tae Kim Dae Beom Park Hoon Cho Md Asadujjaman Jun-Pil Jee |
| author_facet | Ho-Joong Kim Sung Tae Kim Dae Beom Park Hoon Cho Md Asadujjaman Jun-Pil Jee |
| author_sort | Ho-Joong Kim |
| collection | DOAJ |
| description | Mesoporous silica nanoparticles (MSNPs) have been widely used for the delivery of different hydrophilic and hydrophobic drugs owing to their large surface area and ease of chemical alteration. On the other hand, triphenylphosphonium cation (TPP+) with high lipophilicity has a great mitochondrial homing property that stimulates the internalization of drugs into cells. Therefore, we designed a TPP-modified MSNP to enhance the algicidal activity of our new algicidal agent cyclohexyl-(3,4-dichlorobenzyl) amine (DP92). In this study, algicidal activity was evaluated by assessing the growth rate inhibition of two harmful algal blooms (HABs), <i>Heterosigma akashiwo</i> and <i>Heterocapsa circularisquama</i>, after treatment with DP92-loaded MSNP or TPP-MSNP and DP92 in DMSO (as control). For <i>H. akashiwo</i>, the IC<sub>50</sub> values of TPP-MSNP and MSNP are 0.03 ± 0.01 and 0.16 ± 0.03 µM, respectively, whereas the value of the control is 0.27 ± 0.02 µM. For <i>H. circularisquama</i>, the IC<sub>50</sub> values of TPP-MSNP and MSNP are 0.10 ± 0.02 and 0.29 ± 0.02 µM, respectively, whereas the value of the control is 1.90 ± 0.09 µM. Results have indicated that TPP-MSNP efficiently enhanced the algicidal activity of DP92, signifying the prospect of using DP92-loaded TPP-MSNP as an algicidal agent for the superior management of HABs. |
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| language | English |
| last_indexed | 2024-03-09T21:37:50Z |
| publishDate | 2022-10-01 |
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| spelling | doaj.art-fc89d1e07966463b805f043e980a66102023-11-23T20:41:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123191190110.3390/ijms231911901Triphenylphosphonium Modified Mesoporous Silica Nanoparticle for Enhanced Algicidal Efficacy of Cyclohexyl-(3,4-dichlorobenzyl) AmineHo-Joong Kim0Sung Tae Kim1Dae Beom Park2Hoon Cho3Md Asadujjaman4Jun-Pil Jee5Department of Chemistry, Chosun University, Gwangju 61452, KoreaDepartment of Pharmaceutical Engineering, Inje University, Gimhae 50834, KoreaCollege of Pharmacy, Chosun University, Gwangju 61452, KoreaDepartment of Polymer Science and Engineering, Chosun University, Gwangju 61452, KoreaCollege of Pharmacy, Chosun University, Gwangju 61452, KoreaCollege of Pharmacy, Chosun University, Gwangju 61452, KoreaMesoporous silica nanoparticles (MSNPs) have been widely used for the delivery of different hydrophilic and hydrophobic drugs owing to their large surface area and ease of chemical alteration. On the other hand, triphenylphosphonium cation (TPP+) with high lipophilicity has a great mitochondrial homing property that stimulates the internalization of drugs into cells. Therefore, we designed a TPP-modified MSNP to enhance the algicidal activity of our new algicidal agent cyclohexyl-(3,4-dichlorobenzyl) amine (DP92). In this study, algicidal activity was evaluated by assessing the growth rate inhibition of two harmful algal blooms (HABs), <i>Heterosigma akashiwo</i> and <i>Heterocapsa circularisquama</i>, after treatment with DP92-loaded MSNP or TPP-MSNP and DP92 in DMSO (as control). For <i>H. akashiwo</i>, the IC<sub>50</sub> values of TPP-MSNP and MSNP are 0.03 ± 0.01 and 0.16 ± 0.03 µM, respectively, whereas the value of the control is 0.27 ± 0.02 µM. For <i>H. circularisquama</i>, the IC<sub>50</sub> values of TPP-MSNP and MSNP are 0.10 ± 0.02 and 0.29 ± 0.02 µM, respectively, whereas the value of the control is 1.90 ± 0.09 µM. Results have indicated that TPP-MSNP efficiently enhanced the algicidal activity of DP92, signifying the prospect of using DP92-loaded TPP-MSNP as an algicidal agent for the superior management of HABs.https://www.mdpi.com/1422-0067/23/19/11901mesoporoussilicananoparticlealgicidal activityalgicidal agentcyclohexyl-(3,4-dichlorobenzyl) amine |
| spellingShingle | Ho-Joong Kim Sung Tae Kim Dae Beom Park Hoon Cho Md Asadujjaman Jun-Pil Jee Triphenylphosphonium Modified Mesoporous Silica Nanoparticle for Enhanced Algicidal Efficacy of Cyclohexyl-(3,4-dichlorobenzyl) Amine International Journal of Molecular Sciences mesoporous silica nanoparticle algicidal activity algicidal agent cyclohexyl-(3,4-dichlorobenzyl) amine |
| title | Triphenylphosphonium Modified Mesoporous Silica Nanoparticle for Enhanced Algicidal Efficacy of Cyclohexyl-(3,4-dichlorobenzyl) Amine |
| title_full | Triphenylphosphonium Modified Mesoporous Silica Nanoparticle for Enhanced Algicidal Efficacy of Cyclohexyl-(3,4-dichlorobenzyl) Amine |
| title_fullStr | Triphenylphosphonium Modified Mesoporous Silica Nanoparticle for Enhanced Algicidal Efficacy of Cyclohexyl-(3,4-dichlorobenzyl) Amine |
| title_full_unstemmed | Triphenylphosphonium Modified Mesoporous Silica Nanoparticle for Enhanced Algicidal Efficacy of Cyclohexyl-(3,4-dichlorobenzyl) Amine |
| title_short | Triphenylphosphonium Modified Mesoporous Silica Nanoparticle for Enhanced Algicidal Efficacy of Cyclohexyl-(3,4-dichlorobenzyl) Amine |
| title_sort | triphenylphosphonium modified mesoporous silica nanoparticle for enhanced algicidal efficacy of cyclohexyl 3 4 dichlorobenzyl amine |
| topic | mesoporous silica nanoparticle algicidal activity algicidal agent cyclohexyl-(3,4-dichlorobenzyl) amine |
| url | https://www.mdpi.com/1422-0067/23/19/11901 |
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