CHANGE OF THE LEFT VENTRICLE FUNCTIONING IN LYMPHOMA TREATED WITH ANTHRACYCLINE ANTIBIOTICS
Aim. Study of toxic effect of anthracycline anibiotics on the heart in various periods of application.Material and methods. We studied 94 patients with lymphomas before, at the moment and in long-term follow-up of chemotherapy. All patients underwent AHM with HRV and QTc duration. In EchoCG we studi...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2016-01-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/633 |
| _version_ | 1797856994711830528 |
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| author | K. V. Shuykova E. I. Emelina G. E. Gendlin G. I. Storojakov |
| author_facet | K. V. Shuykova E. I. Emelina G. E. Gendlin G. I. Storojakov |
| author_sort | K. V. Shuykova |
| collection | DOAJ |
| description | Aim. Study of toxic effect of anthracycline anibiotics on the heart in various periods of application.Material and methods. We studied 94 patients with lymphomas before, at the moment and in long-term follow-up of chemotherapy. All patients underwent AHM with HRV and QTc duration. In EchoCG we studied systolic and diastolic LV function; the latter — with values of V1/3, IF and RF in the first third of diastole.Results. In some patients at the moment of anthracycline application we found the prolonged QTc with statistically lower HRV and diastolic parameters (IF and RF of LV). In 11 from 24 patients, assessed in dynamics, we found the signs of CHF, followed with consequent decrease of EDV, iEDV amd RF of LV.Conclusion. In some patients at the moment of anthracycline antibiotics load there is covert diastolic dysfunction of the LV and predominance of SNS on the heart that might lead later to remodeling of myocardium with the development of anthracyclineinduced cardiomyopathy. |
| first_indexed | 2024-04-09T20:49:26Z |
| format | Article |
| id | doaj.art-fc8a6096090046029df08d31cacb24f5 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:49:26Z |
| publishDate | 2016-01-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-fc8a6096090046029df08d31cacb24f52023-03-29T21:23:25Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202016-01-0101414610.15829/1560-4071-2016-1-41-46577CHANGE OF THE LEFT VENTRICLE FUNCTIONING IN LYMPHOMA TREATED WITH ANTHRACYCLINE ANTIBIOTICSK. V. Shuykova0E. I. Emelina1G. E. Gendlin2G. I. Storojakov3N. I. P irogov Russian National Research Medical University (RNRMU), Moscow, RussiaN. I. P irogov Russian National Research Medical University (RNRMU), Moscow, RussiaN. I. P irogov Russian National Research Medical University (RNRMU), Moscow, RussiaN. I. P irogov Russian National Research Medical University (RNRMU), Moscow, RussiaAim. Study of toxic effect of anthracycline anibiotics on the heart in various periods of application.Material and methods. We studied 94 patients with lymphomas before, at the moment and in long-term follow-up of chemotherapy. All patients underwent AHM with HRV and QTc duration. In EchoCG we studied systolic and diastolic LV function; the latter — with values of V1/3, IF and RF in the first third of diastole.Results. In some patients at the moment of anthracycline application we found the prolonged QTc with statistically lower HRV and diastolic parameters (IF and RF of LV). In 11 from 24 patients, assessed in dynamics, we found the signs of CHF, followed with consequent decrease of EDV, iEDV amd RF of LV.Conclusion. In some patients at the moment of anthracycline antibiotics load there is covert diastolic dysfunction of the LV and predominance of SNS on the heart that might lead later to remodeling of myocardium with the development of anthracyclineinduced cardiomyopathy.https://russjcardiol.elpub.ru/jour/article/view/633chemotherapyanthracycline cardiotoxicityheart rate variabilitycorrected intervaldiastolic dysfunctionleft ventricle volume in first third of diastoleinjection fractionrelaxation fraction |
| spellingShingle | K. V. Shuykova E. I. Emelina G. E. Gendlin G. I. Storojakov CHANGE OF THE LEFT VENTRICLE FUNCTIONING IN LYMPHOMA TREATED WITH ANTHRACYCLINE ANTIBIOTICS Российский кардиологический журнал chemotherapy anthracycline cardiotoxicity heart rate variability corrected interval diastolic dysfunction left ventricle volume in first third of diastole injection fraction relaxation fraction |
| title | CHANGE OF THE LEFT VENTRICLE FUNCTIONING IN LYMPHOMA TREATED WITH ANTHRACYCLINE ANTIBIOTICS |
| title_full | CHANGE OF THE LEFT VENTRICLE FUNCTIONING IN LYMPHOMA TREATED WITH ANTHRACYCLINE ANTIBIOTICS |
| title_fullStr | CHANGE OF THE LEFT VENTRICLE FUNCTIONING IN LYMPHOMA TREATED WITH ANTHRACYCLINE ANTIBIOTICS |
| title_full_unstemmed | CHANGE OF THE LEFT VENTRICLE FUNCTIONING IN LYMPHOMA TREATED WITH ANTHRACYCLINE ANTIBIOTICS |
| title_short | CHANGE OF THE LEFT VENTRICLE FUNCTIONING IN LYMPHOMA TREATED WITH ANTHRACYCLINE ANTIBIOTICS |
| title_sort | change of the left ventricle functioning in lymphoma treated with anthracycline antibiotics |
| topic | chemotherapy anthracycline cardiotoxicity heart rate variability corrected interval diastolic dysfunction left ventricle volume in first third of diastole injection fraction relaxation fraction |
| url | https://russjcardiol.elpub.ru/jour/article/view/633 |
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