ALDH2 as a potential stem cell-related biomarker in lung adenocarcinoma: Comprehensive multi-omics analysis
Lung adenocarcinoma (LUAD) is the most prevalent lung cancer and one of the leading causes of death. Previous research found a link between LUAD and Aldehyde Dehydrogenase 2 (ALDH2), a member of aldehyde dehydrogenase gene (ALDH) superfamily. In this study, we identified additional useful prognostic...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
|
| Series: | Computational and Structural Biotechnology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037023000910 |
| _version_ | 1797384181297184768 |
|---|---|
| author | Thi-Oanh Tran Thanh Hoa Vo Luu Ho Thanh Lam Nguyen Quoc Khanh Le |
| author_facet | Thi-Oanh Tran Thanh Hoa Vo Luu Ho Thanh Lam Nguyen Quoc Khanh Le |
| author_sort | Thi-Oanh Tran |
| collection | DOAJ |
| description | Lung adenocarcinoma (LUAD) is the most prevalent lung cancer and one of the leading causes of death. Previous research found a link between LUAD and Aldehyde Dehydrogenase 2 (ALDH2), a member of aldehyde dehydrogenase gene (ALDH) superfamily. In this study, we identified additional useful prognostic markers for early LUAD identification and targeting LUAD therapy by analyzing the expression level, epigenetic mechanism, and signaling activities of ALDH2 in LUAD patients. The obtained results demonstrated that ALDH2 gene and protein expression significantly downregulated in LUAD patient samples. Furthermore, The American Joint Committee on Cancer (AJCC) reported that diminished ALDH2 expression was closely linked to worse overall survival (OS) in different stages of LUAD. Considerably, ALDH2 showed aberrant DNA methylation status in LUAD cancer. ALDH2 was found to be downregulated in the proteomic expression profile of several cell biology signaling pathways, particularly stem cell-related pathways. Finally, the relationship of ALDH2 activity with stem cell-related factors and immune system were reported. In conclusion, the downregulation of ALDH2, abnormal DNA methylation, and the consequent deficit of stemness signaling pathways are relevant prognostic and therapeutic markers in LUAD. |
| first_indexed | 2024-03-08T21:31:47Z |
| format | Article |
| id | doaj.art-fc8ab5a22ed24fd5aca1f450d70638c1 |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-03-08T21:31:47Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-fc8ab5a22ed24fd5aca1f450d70638c12023-12-21T07:31:08ZengElsevierComputational and Structural Biotechnology Journal2001-03702023-01-012119211929ALDH2 as a potential stem cell-related biomarker in lung adenocarcinoma: Comprehensive multi-omics analysisThi-Oanh Tran0Thanh Hoa Vo1Luu Ho Thanh Lam2Nguyen Quoc Khanh Le3International Ph.D. Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan; Hematology and Blood Transfusion Center, Bach Mai Hospital, No.78, Giai Phong street, Hanoi, Viet NamDepartment of Science, School of Science and Computing, South East Technological University, Waterford X91 K0EK, Ireland; Pharmaceutical and Molecular Biotechnology Research Center (PMBRC), South East Technological University, Waterford X91 K0EK, IrelandDepartment of Pediatrics, Pham Ngoc Thach University of Medicine, Ho Chi Minh city, Viet Nam; Children’s Hospital 1, Ho Chi Minh city, Viet NamProfessional Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei 106, Taiwan; Research Center for Artificial Intelligence in Medicine, Taipei Medical University, Taipei 106, Taiwan; Translational Imaging Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan; Corresponding author at: Professional Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei 106, Taiwan.Lung adenocarcinoma (LUAD) is the most prevalent lung cancer and one of the leading causes of death. Previous research found a link between LUAD and Aldehyde Dehydrogenase 2 (ALDH2), a member of aldehyde dehydrogenase gene (ALDH) superfamily. In this study, we identified additional useful prognostic markers for early LUAD identification and targeting LUAD therapy by analyzing the expression level, epigenetic mechanism, and signaling activities of ALDH2 in LUAD patients. The obtained results demonstrated that ALDH2 gene and protein expression significantly downregulated in LUAD patient samples. Furthermore, The American Joint Committee on Cancer (AJCC) reported that diminished ALDH2 expression was closely linked to worse overall survival (OS) in different stages of LUAD. Considerably, ALDH2 showed aberrant DNA methylation status in LUAD cancer. ALDH2 was found to be downregulated in the proteomic expression profile of several cell biology signaling pathways, particularly stem cell-related pathways. Finally, the relationship of ALDH2 activity with stem cell-related factors and immune system were reported. In conclusion, the downregulation of ALDH2, abnormal DNA methylation, and the consequent deficit of stemness signaling pathways are relevant prognostic and therapeutic markers in LUAD.http://www.sciencedirect.com/science/article/pii/S2001037023000910Aldehyde Dehydrogenase 2Cancer stem cellsDNA methylationGene expressionLung adenocarcinomaProtein expression |
| spellingShingle | Thi-Oanh Tran Thanh Hoa Vo Luu Ho Thanh Lam Nguyen Quoc Khanh Le ALDH2 as a potential stem cell-related biomarker in lung adenocarcinoma: Comprehensive multi-omics analysis Computational and Structural Biotechnology Journal Aldehyde Dehydrogenase 2 Cancer stem cells DNA methylation Gene expression Lung adenocarcinoma Protein expression |
| title | ALDH2 as a potential stem cell-related biomarker in lung adenocarcinoma: Comprehensive multi-omics analysis |
| title_full | ALDH2 as a potential stem cell-related biomarker in lung adenocarcinoma: Comprehensive multi-omics analysis |
| title_fullStr | ALDH2 as a potential stem cell-related biomarker in lung adenocarcinoma: Comprehensive multi-omics analysis |
| title_full_unstemmed | ALDH2 as a potential stem cell-related biomarker in lung adenocarcinoma: Comprehensive multi-omics analysis |
| title_short | ALDH2 as a potential stem cell-related biomarker in lung adenocarcinoma: Comprehensive multi-omics analysis |
| title_sort | aldh2 as a potential stem cell related biomarker in lung adenocarcinoma comprehensive multi omics analysis |
| topic | Aldehyde Dehydrogenase 2 Cancer stem cells DNA methylation Gene expression Lung adenocarcinoma Protein expression |
| url | http://www.sciencedirect.com/science/article/pii/S2001037023000910 |
| work_keys_str_mv | AT thioanhtran aldh2asapotentialstemcellrelatedbiomarkerinlungadenocarcinomacomprehensivemultiomicsanalysis AT thanhhoavo aldh2asapotentialstemcellrelatedbiomarkerinlungadenocarcinomacomprehensivemultiomicsanalysis AT luuhothanhlam aldh2asapotentialstemcellrelatedbiomarkerinlungadenocarcinomacomprehensivemultiomicsanalysis AT nguyenquockhanhle aldh2asapotentialstemcellrelatedbiomarkerinlungadenocarcinomacomprehensivemultiomicsanalysis |