Tumor microenvironment responsive drug delivery systems
Conventional tumor-targeted drug delivery systems (DDSs) face challenges, such as unsatisfied systemic circulation, low targeting efficiency, poor tumoral penetration, and uncontrolled drug release. Recently, tumor cellular molecules-triggered DDSs have aroused great interests in addressing such dil...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-07-01
|
| Series: | Asian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087619304714 |
| _version_ | 1818291940833099776 |
|---|---|
| author | Qunye He Jun Chen Jianhua Yan Shundong Cai Hongjie Xiong Yanfei Liu Dongming Peng Miao Mo Zhenbao Liu |
| author_facet | Qunye He Jun Chen Jianhua Yan Shundong Cai Hongjie Xiong Yanfei Liu Dongming Peng Miao Mo Zhenbao Liu |
| author_sort | Qunye He |
| collection | DOAJ |
| description | Conventional tumor-targeted drug delivery systems (DDSs) face challenges, such as unsatisfied systemic circulation, low targeting efficiency, poor tumoral penetration, and uncontrolled drug release. Recently, tumor cellular molecules-triggered DDSs have aroused great interests in addressing such dilemmas. With the introduction of several additional functionalities, the properties of these smart DDSs including size, surface charge and ligand exposure can response to different tumor microenvironments for a more efficient tumor targeting, and eventually achieve desired drug release for an optimized therapeutic efficiency. This review highlights the recent research progresses on smart tumor environment responsive drug delivery systems for targeted drug delivery. Dynamic targeting strategies and functional moieties sensitive to a variety of tumor cellular stimuli, including pH, glutathione, adenosine-triphosphate, reactive oxygen species, enzyme and inflammatory factors are summarized. Special emphasis of this review is placed on their responsive mechanisms, drug loading models, drawbacks and merits. Several typical multi-stimuli responsive DDSs are listed. And the main challenges and potential future development are discussed. |
| first_indexed | 2024-12-13T02:52:03Z |
| format | Article |
| id | doaj.art-fc8cc3cef06449658d30ea2b818adebf |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-12-13T02:52:03Z |
| publishDate | 2020-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-fc8cc3cef06449658d30ea2b818adebf2022-12-22T00:02:02ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762020-07-01154416448Tumor microenvironment responsive drug delivery systemsQunye He0Jun Chen1Jianhua Yan2Shundong Cai3Hongjie Xiong4Yanfei Liu5Dongming Peng6Miao Mo7Zhenbao Liu8Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, ChinaSchool of Chemistry and Chemical Engineering, Central South University, Changsha 410083, ChinaSchool of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, ChinaDepartment of Urology, Xiangya Hospital, Central South University, Changsha 410008, China; Corresponding authors. Central South University, No. 172, Tongzipo Road, Changsha 410013, China. Tel.: +86 13723886533.Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China; Corresponding authors. Central South University, No. 172, Tongzipo Road, Changsha 410013, China. Tel.: +86 13723886533.Conventional tumor-targeted drug delivery systems (DDSs) face challenges, such as unsatisfied systemic circulation, low targeting efficiency, poor tumoral penetration, and uncontrolled drug release. Recently, tumor cellular molecules-triggered DDSs have aroused great interests in addressing such dilemmas. With the introduction of several additional functionalities, the properties of these smart DDSs including size, surface charge and ligand exposure can response to different tumor microenvironments for a more efficient tumor targeting, and eventually achieve desired drug release for an optimized therapeutic efficiency. This review highlights the recent research progresses on smart tumor environment responsive drug delivery systems for targeted drug delivery. Dynamic targeting strategies and functional moieties sensitive to a variety of tumor cellular stimuli, including pH, glutathione, adenosine-triphosphate, reactive oxygen species, enzyme and inflammatory factors are summarized. Special emphasis of this review is placed on their responsive mechanisms, drug loading models, drawbacks and merits. Several typical multi-stimuli responsive DDSs are listed. And the main challenges and potential future development are discussed.http://www.sciencedirect.com/science/article/pii/S1818087619304714Cancer therapyStimuli responsiveDynamic targetingDrug delivery systemControlled release |
| spellingShingle | Qunye He Jun Chen Jianhua Yan Shundong Cai Hongjie Xiong Yanfei Liu Dongming Peng Miao Mo Zhenbao Liu Tumor microenvironment responsive drug delivery systems Asian Journal of Pharmaceutical Sciences Cancer therapy Stimuli responsive Dynamic targeting Drug delivery system Controlled release |
| title | Tumor microenvironment responsive drug delivery systems |
| title_full | Tumor microenvironment responsive drug delivery systems |
| title_fullStr | Tumor microenvironment responsive drug delivery systems |
| title_full_unstemmed | Tumor microenvironment responsive drug delivery systems |
| title_short | Tumor microenvironment responsive drug delivery systems |
| title_sort | tumor microenvironment responsive drug delivery systems |
| topic | Cancer therapy Stimuli responsive Dynamic targeting Drug delivery system Controlled release |
| url | http://www.sciencedirect.com/science/article/pii/S1818087619304714 |
| work_keys_str_mv | AT qunyehe tumormicroenvironmentresponsivedrugdeliverysystems AT junchen tumormicroenvironmentresponsivedrugdeliverysystems AT jianhuayan tumormicroenvironmentresponsivedrugdeliverysystems AT shundongcai tumormicroenvironmentresponsivedrugdeliverysystems AT hongjiexiong tumormicroenvironmentresponsivedrugdeliverysystems AT yanfeiliu tumormicroenvironmentresponsivedrugdeliverysystems AT dongmingpeng tumormicroenvironmentresponsivedrugdeliverysystems AT miaomo tumormicroenvironmentresponsivedrugdeliverysystems AT zhenbaoliu tumormicroenvironmentresponsivedrugdeliverysystems |