Biomimetic vascularized adipose-derived mesenchymal stem cells bone-periosteum graft enhances angiogenesis and osteogenesis in a male rabbit spine fusion model

Biomimetic vascularized adipose-derived mesenchymal stem cells bone-periosteum graft enhances angiogenesis and osteogenesis in a male rabbit spine fusion model

Aims: Several artificial bone grafts have been developed but fail to achieve anticipated osteogenesis due to their insufficient neovascularization capacity and periosteum support. This study aimed to develop a vascularized bone-periosteum construct (VBPC) to provide better angiogenesis and osteogene...

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Bibliographic Details
Main Authors:	Tsai-Sheng Fu, Wei-Chuan Chen, Ying-Chih Wang, Chia-Wei Chang, Tung-yi Lin, Chak-Bor Wong
Format:	Article
Language:	English
Published:	The British Editorial Society of Bone & Joint Surgery 2023-12-01
Series:	Bone & Joint Research
Subjects:	adipose-derived mesenchymal stem cell tissue engineering osteogenesis angiogenesis biomimetic bone graft adipose-derived mesenchymal stem cells spinal fusion surgery ossification periosteums rabbit model bone formation collagen staining
Online Access:	https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.1212.BJR-2023-0013.R1

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