Non-alcoholic fatty liver disease is associated with a worse prognosis in patients with heart failure: A pool analysis
Background and aimsNon-alcoholic fatty liver disease (NAFLD) is associated with a higher risk of heart failure (HF) than those without NAFLD. However, the prognostic impact of NAFLD in HF is still controversial. This meta-analysis aimed to explore the association between NAFLD and the risk of advers...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1167608/full |
| _version_ | 1797843818083516416 |
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| author | Min Qiu Jiahuan Li Shali Hao Haoxiao Zheng Xiaojie Zhang Hailan Zhu Xiaolin Zhu Yunzhao Hu Xiaoyan Cai Yuli Huang Yuli Huang Yuli Huang |
| author_facet | Min Qiu Jiahuan Li Shali Hao Haoxiao Zheng Xiaojie Zhang Hailan Zhu Xiaolin Zhu Yunzhao Hu Xiaoyan Cai Yuli Huang Yuli Huang Yuli Huang |
| author_sort | Min Qiu |
| collection | DOAJ |
| description | Background and aimsNon-alcoholic fatty liver disease (NAFLD) is associated with a higher risk of heart failure (HF) than those without NAFLD. However, the prognostic impact of NAFLD in HF is still controversial. This meta-analysis aimed to explore the association between NAFLD and the risk of adverse outcomes in patients with HF.MethodsWe searched multiple electronic databases (Embase, PubMed, and Google Scholar) for potentially related studies up to June 30, 2022. Cohort studies reported multivariable adjusted relative risks and 95% confidence intervals (CIs) of adverse outcomes in HF patients with NAFLD comparing those without NAFLD were included for analysis.ResultsA total of six studies involving 12,374 patients with HF were included for analysis, with a median follow-up duration of 2.5 years. The pooled analysis showed that HF patients with NAFLD were associated with a significantly increased risk of major composite adverse outcomes (HR 1.61, 95% CI 1.25-2.07), all-cause mortality (HR 1.66, 95% CI 1.39-1.98), and HF hospitalization or re-hospitalization (HR 1.71, 95% CI 1.03-2.86).ConclusionNAFLD is associated with a worse prognosis in patients with HF. Effective screening and treatment strategies are needed to improve the prognosis in HF patients with NAFLD. |
| first_indexed | 2024-04-09T17:12:07Z |
| format | Article |
| id | doaj.art-fc8f0e9e4d1549e889f2b7d45bc0bc7a |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T17:12:07Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-fc8f0e9e4d1549e889f2b7d45bc0bc7a2023-04-20T05:57:12ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-04-011410.3389/fendo.2023.11676081167608Non-alcoholic fatty liver disease is associated with a worse prognosis in patients with heart failure: A pool analysisMin Qiu0Jiahuan Li1Shali Hao2Haoxiao Zheng3Xiaojie Zhang4Hailan Zhu5Xiaolin Zhu6Yunzhao Hu7Xiaoyan Cai8Yuli Huang9Yuli Huang10Yuli Huang11Department of Cardiology, Shunde Hospital, Southern Medical University, Foshan, ChinaDepartment of Cardiology, Shunde Hospital, Southern Medical University, Foshan, ChinaDepartment of Cardiology, Shunde Hospital, Southern Medical University, Foshan, ChinaDepartment of Cardiology, Shunde Hospital, Southern Medical University, Foshan, ChinaDepartment of Cardiology, Shunde Hospital, Southern Medical University, Foshan, ChinaDepartment of Cardiology, Shunde Hospital, Southern Medical University, Foshan, ChinaDepartment of Cardiology, Shunde Hospital, Southern Medical University, Foshan, ChinaDepartment of Cardiology, Shunde Hospital, Southern Medical University, Foshan, ChinaDepartment of Scientific Research and Education, Shunde Hospital, Southern Medical University, Foshan, ChinaDepartment of Cardiology, Shunde Hospital, Southern Medical University, Foshan, ChinaGuangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Southern Medical University, Guangzhou, ChinaThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, AustraliaBackground and aimsNon-alcoholic fatty liver disease (NAFLD) is associated with a higher risk of heart failure (HF) than those without NAFLD. However, the prognostic impact of NAFLD in HF is still controversial. This meta-analysis aimed to explore the association between NAFLD and the risk of adverse outcomes in patients with HF.MethodsWe searched multiple electronic databases (Embase, PubMed, and Google Scholar) for potentially related studies up to June 30, 2022. Cohort studies reported multivariable adjusted relative risks and 95% confidence intervals (CIs) of adverse outcomes in HF patients with NAFLD comparing those without NAFLD were included for analysis.ResultsA total of six studies involving 12,374 patients with HF were included for analysis, with a median follow-up duration of 2.5 years. The pooled analysis showed that HF patients with NAFLD were associated with a significantly increased risk of major composite adverse outcomes (HR 1.61, 95% CI 1.25-2.07), all-cause mortality (HR 1.66, 95% CI 1.39-1.98), and HF hospitalization or re-hospitalization (HR 1.71, 95% CI 1.03-2.86).ConclusionNAFLD is associated with a worse prognosis in patients with HF. Effective screening and treatment strategies are needed to improve the prognosis in HF patients with NAFLD.https://www.frontiersin.org/articles/10.3389/fendo.2023.1167608/fullheart failurenon-alcoholic fatty liver diseaseprognosismortalitymeta-analysis |
| spellingShingle | Min Qiu Jiahuan Li Shali Hao Haoxiao Zheng Xiaojie Zhang Hailan Zhu Xiaolin Zhu Yunzhao Hu Xiaoyan Cai Yuli Huang Yuli Huang Yuli Huang Non-alcoholic fatty liver disease is associated with a worse prognosis in patients with heart failure: A pool analysis Frontiers in Endocrinology heart failure non-alcoholic fatty liver disease prognosis mortality meta-analysis |
| title | Non-alcoholic fatty liver disease is associated with a worse prognosis in patients with heart failure: A pool analysis |
| title_full | Non-alcoholic fatty liver disease is associated with a worse prognosis in patients with heart failure: A pool analysis |
| title_fullStr | Non-alcoholic fatty liver disease is associated with a worse prognosis in patients with heart failure: A pool analysis |
| title_full_unstemmed | Non-alcoholic fatty liver disease is associated with a worse prognosis in patients with heart failure: A pool analysis |
| title_short | Non-alcoholic fatty liver disease is associated with a worse prognosis in patients with heart failure: A pool analysis |
| title_sort | non alcoholic fatty liver disease is associated with a worse prognosis in patients with heart failure a pool analysis |
| topic | heart failure non-alcoholic fatty liver disease prognosis mortality meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1167608/full |
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