The challenges of creating a universal influenza vaccine
The lack of population immunity to the periodically emerging pandemic influenza strains makes influenza infection especially dangerous. The fragmented nature of the influenza virus genome contributes to the formation of influenza virus reassortants containing genomic fragments from different strains...
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| Format: | Article |
| Language: | English |
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Doctrine
2016-06-01
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| Series: | Microbiology Independent Research Journal |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.18527/2500-2236-2016-3-1-31-41 |
| _version_ | 1797221116304949248 |
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| author | Andrej Y. Egorov |
| author_facet | Andrej Y. Egorov |
| author_sort | Andrej Y. Egorov |
| collection | DOAJ |
| description | The lack of population immunity to the periodically emerging pandemic influenza strains makes influenza infection especially dangerous. The fragmented nature of the influenza virus genome contributes to the formation of influenza virus reassortants containing genomic fragments from different strains. This mechanism is the main reason for the natural influenza virus antigenic diversity as well as for the occurrence of influenza pandemics. Vaccination is the best measure to prevent the spread of influenza infection, but the efficacy of existing vaccines is not sufficient, especially for the elderly and small children. Specific immunity, developed after disease or immunization, poorly protects against infection by influenza viruses of another subtype. In this regard, there is an urgent need for a more effective universal influenza vaccine that provides a long-lasting broad cross-protective immunity, and is able to protect against influenza A and B viruses of all known subtypes. The basic approaches to as well as challenges of creating such a vaccine are discussed in this review. |
| first_indexed | 2024-03-11T07:16:07Z |
| format | Article |
| id | doaj.art-fc8f47e2b69348ad85ea0ec2b369e024 |
| institution | Directory Open Access Journal |
| issn | 2500-2236 |
| language | English |
| last_indexed | 2024-04-24T13:00:19Z |
| publishDate | 2016-06-01 |
| publisher | Doctrine |
| record_format | Article |
| series | Microbiology Independent Research Journal |
| spelling | doaj.art-fc8f47e2b69348ad85ea0ec2b369e0242024-04-05T16:00:35ZengDoctrineMicrobiology Independent Research Journal2500-22362016-06-0131314110.18527/2500-2236-2016-3-1-31-41The challenges of creating a universal influenza vaccineAndrej Y. EgorovThe lack of population immunity to the periodically emerging pandemic influenza strains makes influenza infection especially dangerous. The fragmented nature of the influenza virus genome contributes to the formation of influenza virus reassortants containing genomic fragments from different strains. This mechanism is the main reason for the natural influenza virus antigenic diversity as well as for the occurrence of influenza pandemics. Vaccination is the best measure to prevent the spread of influenza infection, but the efficacy of existing vaccines is not sufficient, especially for the elderly and small children. Specific immunity, developed after disease or immunization, poorly protects against infection by influenza viruses of another subtype. In this regard, there is an urgent need for a more effective universal influenza vaccine that provides a long-lasting broad cross-protective immunity, and is able to protect against influenza A and B viruses of all known subtypes. The basic approaches to as well as challenges of creating such a vaccine are discussed in this review.https://www.scienceopen.com/hosted-document?doi=10.18527/2500-2236-2016-3-1-31-41 |
| spellingShingle | Andrej Y. Egorov The challenges of creating a universal influenza vaccine Microbiology Independent Research Journal |
| title | The challenges of creating a universal influenza vaccine |
| title_full | The challenges of creating a universal influenza vaccine |
| title_fullStr | The challenges of creating a universal influenza vaccine |
| title_full_unstemmed | The challenges of creating a universal influenza vaccine |
| title_short | The challenges of creating a universal influenza vaccine |
| title_sort | challenges of creating a universal influenza vaccine |
| url | https://www.scienceopen.com/hosted-document?doi=10.18527/2500-2236-2016-3-1-31-41 |
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