Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease
Abstract Conflicting results have been reported regarding the effectiveness of light treatment (LT) in patients with Alzheimer’s disease (AD). We investigated the effectiveness of blue-enriched white LT on sleep, cognition, mood and behavior in patients with mild and moderate AD. The treatment group...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-05-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-89521-9 |
| _version_ | 1818840875496636416 |
|---|---|
| author | Seong Jae Kim Sun Hee Lee In Bum Suh Jae-Won Jang Jin Hyeong Jhoo Jung Hie Lee |
| author_facet | Seong Jae Kim Sun Hee Lee In Bum Suh Jae-Won Jang Jin Hyeong Jhoo Jung Hie Lee |
| author_sort | Seong Jae Kim |
| collection | DOAJ |
| description | Abstract Conflicting results have been reported regarding the effectiveness of light treatment (LT) in patients with Alzheimer’s disease (AD). We investigated the effectiveness of blue-enriched white LT on sleep, cognition, mood and behavior in patients with mild and moderate AD. The treatment group (n = 14) sat about 60 cm away from a small (136 × 73 × 16 mm) LED light box for 1 h each morning for 2 weeks. The control group (n = 11) wore dark, blue-attenuating sunglasses during the 1 h exposures. The morning light started 9–10 h after each individual’s dim light melatonin onset (DLMO). Assessments were done at baseline (T0), immediate post-treatment (T1), and 4 weeks after the end of the 2 weeks of LT (T2). Sleep was measured by actigraphy. Blue-enriched LT had a significantly better effect on the Pittsburgh Sleep Quality Index at T2 compared to blue-attenuated LT, and a trend of better effectiveness on total sleep time at T2. There was a significant increase in Mini-Mental State Examination score at T2 after blue-enriched LT than that at T0. Our findings suggest that morning blue-enriched LT has a benefit in improving sleep and cognitive function in AD patients. |
| first_indexed | 2024-12-19T04:17:08Z |
| format | Article |
| id | doaj.art-fc8fd5815e1d470eb087dc95c370be34 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T04:17:08Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-fc8fd5815e1d470eb087dc95c370be342022-12-21T20:36:17ZengNature PortfolioScientific Reports2045-23222021-05-0111111210.1038/s41598-021-89521-9Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s diseaseSeong Jae Kim0Sun Hee Lee1In Bum Suh2Jae-Won Jang3Jin Hyeong Jhoo4Jung Hie Lee5Department of Psychiatry, Cheongju HospitalDepartment of Psychiatry, Silverheals HospitalDepartment of Laboratory Medicine, Kangwon National University HospitalDepartment of Neurology, Kangwon National University HospitalDepartment of Psychiatry, Kangwon National University HospitalDepartment of Psychiatry, Kangwon National University HospitalAbstract Conflicting results have been reported regarding the effectiveness of light treatment (LT) in patients with Alzheimer’s disease (AD). We investigated the effectiveness of blue-enriched white LT on sleep, cognition, mood and behavior in patients with mild and moderate AD. The treatment group (n = 14) sat about 60 cm away from a small (136 × 73 × 16 mm) LED light box for 1 h each morning for 2 weeks. The control group (n = 11) wore dark, blue-attenuating sunglasses during the 1 h exposures. The morning light started 9–10 h after each individual’s dim light melatonin onset (DLMO). Assessments were done at baseline (T0), immediate post-treatment (T1), and 4 weeks after the end of the 2 weeks of LT (T2). Sleep was measured by actigraphy. Blue-enriched LT had a significantly better effect on the Pittsburgh Sleep Quality Index at T2 compared to blue-attenuated LT, and a trend of better effectiveness on total sleep time at T2. There was a significant increase in Mini-Mental State Examination score at T2 after blue-enriched LT than that at T0. Our findings suggest that morning blue-enriched LT has a benefit in improving sleep and cognitive function in AD patients.https://doi.org/10.1038/s41598-021-89521-9 |
| spellingShingle | Seong Jae Kim Sun Hee Lee In Bum Suh Jae-Won Jang Jin Hyeong Jhoo Jung Hie Lee Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease Scientific Reports |
| title | Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease |
| title_full | Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease |
| title_fullStr | Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease |
| title_full_unstemmed | Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease |
| title_short | Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease |
| title_sort | positive effect of timed blue enriched white light on sleep and cognition in patients with mild and moderate alzheimer s disease |
| url | https://doi.org/10.1038/s41598-021-89521-9 |
| work_keys_str_mv | AT seongjaekim positiveeffectoftimedblueenrichedwhitelightonsleepandcognitioninpatientswithmildandmoderatealzheimersdisease AT sunheelee positiveeffectoftimedblueenrichedwhitelightonsleepandcognitioninpatientswithmildandmoderatealzheimersdisease AT inbumsuh positiveeffectoftimedblueenrichedwhitelightonsleepandcognitioninpatientswithmildandmoderatealzheimersdisease AT jaewonjang positiveeffectoftimedblueenrichedwhitelightonsleepandcognitioninpatientswithmildandmoderatealzheimersdisease AT jinhyeongjhoo positiveeffectoftimedblueenrichedwhitelightonsleepandcognitioninpatientswithmildandmoderatealzheimersdisease AT junghielee positiveeffectoftimedblueenrichedwhitelightonsleepandcognitioninpatientswithmildandmoderatealzheimersdisease |