Pharmacokinetics and Pharmacodynamics of a Depolymerized Glycosaminoglycan from <i>Holothuria fuscopunctata</i>, a Novel Anticoagulant Candidate, in Rats by Bioanalytical Methods

Pharmacokinetics and Pharmacodynamics of a Depolymerized Glycosaminoglycan from <i>Holothuria fuscopunctata</i>, a Novel Anticoagulant Candidate, in Rats by Bioanalytical Methods

dHG-5 (Mw 5.3 kD) is a depolymerized glycosaminoglycan from sea cucumber <i>Holothuria fuscopunctata</i>. As a selective inhibitor of intrinsic Xase (iXase), preclinical study showed it was a promising anticoagulant candidate without obvious bleeding risk. In this work, two bioanalytical...

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Bibliographic Details
Main Authors: Shuang Liu, Taocui Zhang, Huifang Sun, Lisha Lin, Na Gao, Weili Wang, Sujuan Li, Jinhua Zhao
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Marine Drugs
Subjects:
pharmacokinetics
pharmacodynamics
anticoagulant
fucosylated glycosaminoglycan
dHG-5
method validation
Online Access:https://www.mdpi.com/1660-3397/19/4/212

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