Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers
ABSTRACT: The present study provides the first information about the safety of a new influenza viral vector vaccine expressing the Brucella ribosomal protein L7/L12 or Omp16 containing the adjuvant Montanide Gel01 in pregnant heifers. Immunization of pregnant heifers was conducted via the conjunctiv...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Santa Maria
2016-01-01
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| Series: | Ciência Rural |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000100114&lng=en&tlng=en |
| _version_ | 1819206727277477888 |
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| author | Kaissar Tabynov Sholpan Ryskeldinova Zhailaubay Kydyrbayev Abylai Sansyzbay |
| author_facet | Kaissar Tabynov Sholpan Ryskeldinova Zhailaubay Kydyrbayev Abylai Sansyzbay |
| author_sort | Kaissar Tabynov |
| collection | DOAJ |
| description | ABSTRACT: The present study provides the first information about the safety of a new influenza viral vector vaccine expressing the Brucella ribosomal protein L7/L12 or Omp16 containing the adjuvant Montanide Gel01 in pregnant heifers. Immunization of pregnant heifers was conducted via the conjunctival (n=10) or subcutaneous (n=10) route using cross prime and booster vaccination schedules at an interval of 28 days. The vector vaccine was evaluated in comparison with positive control groups vaccinated with B. abortus S19 (n=10) or B. abortus RB51 (n=10) and a negative (PBS+Montanide Gel01; n=10) control group. Clinical studies, thermometry, assessment of local reactogenicity and observation of abortion showed that the vector vaccine via the conjunctival or subcutaneous route was completely safe for pregnant heifers compared to the commercial vaccines B. abortus S19 or B. abortus RB51. The only single adverse event was the formation of infiltration at the site of subcutaneous injection; this reaction was not observed for the conjunctival route. |
| first_indexed | 2024-12-23T05:12:12Z |
| format | Article |
| id | doaj.art-fc9132afd2c349f7a94aadbb1b24c2db |
| institution | Directory Open Access Journal |
| issn | 1678-4596 |
| language | English |
| last_indexed | 2024-12-23T05:12:12Z |
| publishDate | 2016-01-01 |
| publisher | Universidade Federal de Santa Maria |
| record_format | Article |
| series | Ciência Rural |
| spelling | doaj.art-fc9132afd2c349f7a94aadbb1b24c2db2022-12-21T17:58:57ZengUniversidade Federal de Santa MariaCiência Rural1678-45962016-01-0146111411810.1590/0103-8478cr20150497S0103-84782016000100114Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifersKaissar TabynovSholpan RyskeldinovaZhailaubay KydyrbayevAbylai SansyzbayABSTRACT: The present study provides the first information about the safety of a new influenza viral vector vaccine expressing the Brucella ribosomal protein L7/L12 or Omp16 containing the adjuvant Montanide Gel01 in pregnant heifers. Immunization of pregnant heifers was conducted via the conjunctival (n=10) or subcutaneous (n=10) route using cross prime and booster vaccination schedules at an interval of 28 days. The vector vaccine was evaluated in comparison with positive control groups vaccinated with B. abortus S19 (n=10) or B. abortus RB51 (n=10) and a negative (PBS+Montanide Gel01; n=10) control group. Clinical studies, thermometry, assessment of local reactogenicity and observation of abortion showed that the vector vaccine via the conjunctival or subcutaneous route was completely safe for pregnant heifers compared to the commercial vaccines B. abortus S19 or B. abortus RB51. The only single adverse event was the formation of infiltration at the site of subcutaneous injection; this reaction was not observed for the conjunctival route.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000100114&lng=en&tlng=enBrucella abortusvacinavetor viralsegurançanovilha em gestaçãotermometriareatogenicidadeaborto |
| spellingShingle | Kaissar Tabynov Sholpan Ryskeldinova Zhailaubay Kydyrbayev Abylai Sansyzbay Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers Ciência Rural Brucella abortus vacina vetor viral segurança novilha em gestação termometria reatogenicidade aborto |
| title | Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers |
| title_full | Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers |
| title_fullStr | Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers |
| title_full_unstemmed | Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers |
| title_short | Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers |
| title_sort | safety of the novel influenza viral vector brucella abortus vaccine in pregnant heifers |
| topic | Brucella abortus vacina vetor viral segurança novilha em gestação termometria reatogenicidade aborto |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000100114&lng=en&tlng=en |
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