Significance of changes in general clinical analysis of blood and thyroid status in people with neoplasm of the thyroid gland

Background. One of the major challenges of modern medicine is prevention and early detection of diseases, especially malignant tumors, since the stage does influence the prognosis and treatment costs. Thyroid involvement is currently one of the leading endocrine disorders in terms of overall morbidi...

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Main Authors: М. Ю. Поліон, Н. О. Гладких, О. І. Залюбовська, П. О. Гриценко
Format: Article
Language:English
Published: National Academy of Medical Sciences of Ukraine. Grigoriev Institute for Medical Radiology and Oncology 2021-03-01
Series:Український радіологічний та онкологічний журнал
Subjects:
Online Access:https://ukroj.com/index.php/journal/article/view/72
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author М. Ю. Поліон
Н. О. Гладких
О. І. Залюбовська
П. О. Гриценко
author_facet М. Ю. Поліон
Н. О. Гладких
О. І. Залюбовська
П. О. Гриценко
author_sort М. Ю. Поліон
collection DOAJ
description Background. One of the major challenges of modern medicine is prevention and early detection of diseases, especially malignant tumors, since the stage does influence the prognosis and treatment costs. Thyroid involvement is currently one of the leading endocrine disorders in terms of overall morbidity and prevalence in the world. Thyroid cancer is one of the localizations, which being timely detected and properly treated, has a favorable prognosis, when 20–30-year survival rate exceeds 90 %. Therefore, the search for simple, minimally invasive, but highly informative techniques for optimizing the algorithms for diagnosis, differential diagnosis and monitoring of this disease remains a priority. Purpose – to determine and substantiate the diagnostic value of comprehensive assessment of the thyroid status and full blood count values in patients with thyroid nodules. Materials and methods. The study involved 60 patients with thyroid nodules, which according to ultrasonography (US) of the thyroid were classified as TR-4 category of thyroid nodules, TIRADS scale (4–6 points, suspected malignant thyroid changes). The examination included the following: questionnaire, ultrasound examination with fine-needle aspiration puncture biopsy, cytological examination, counting the thyroid hormone concentration, full blood count. The study was carried out at the premises of State Institution “Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine”. Results. Assessment of thyroid status of patients with thyroid nodules showed a significant correlation between the severity of thyroid malignancy and TSH levels (according to Kruskal – Wallis test, H = 7.30, p < 0.05), FT4 (H = 17.64, p < 0.001) and FT3 (H = 12.41, p < 0.01). Patients of Group I with benign thyroid process showed significant (p < 0.05) decrease in total hemoglobin along with significantly frequent (p < 0.05) microcytic anemia. According to the studies, Group II had a significant (p < 0.05) decrease in total platelet count and plateletcrit, as well as an increased average platelet volume and the percentage of large platelets compared to Group I. The blood values in malignant thyroid process (Group III) are characterized by increased levels of leukocytes and the proportion of eosinophils and basophils in the leukocyte formula compared to Group II (p < 0.05). Conclusions. The outcomes of comprehensive assessment of thyroid status and full blood count values in patients with thyroid nodules can be used in preoperative diagnosis as a differential prognostic tool to assess their malignant potential.
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spelling doaj.art-fc923217fd1e45a5a28ae5f7e90b52582022-12-21T21:59:18ZengNational Academy of Medical Sciences of Ukraine. Grigoriev Institute for Medical Radiology and OncologyУкраїнський радіологічний та онкологічний журнал2708-71662708-71742021-03-01291455710.46879/ukroj.1.2021.45-5772Significance of changes in general clinical analysis of blood and thyroid status in people with neoplasm of the thyroid glandМ. Ю. Поліон0Н. О. Гладких1О. І. Залюбовська2П. О. Гриценко3State Institution «Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine», Dnipro, UkraineKharkiv National Medical University of the Ministry of Health of Ukraine, Kharkiv, UkraineKharkiv National Medical University of the Ministry of Health of Ukraine, Kharkiv, UkraineState Institution «Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine», Dnipro, UkraineBackground. One of the major challenges of modern medicine is prevention and early detection of diseases, especially malignant tumors, since the stage does influence the prognosis and treatment costs. Thyroid involvement is currently one of the leading endocrine disorders in terms of overall morbidity and prevalence in the world. Thyroid cancer is one of the localizations, which being timely detected and properly treated, has a favorable prognosis, when 20–30-year survival rate exceeds 90 %. Therefore, the search for simple, minimally invasive, but highly informative techniques for optimizing the algorithms for diagnosis, differential diagnosis and monitoring of this disease remains a priority. Purpose – to determine and substantiate the diagnostic value of comprehensive assessment of the thyroid status and full blood count values in patients with thyroid nodules. Materials and methods. The study involved 60 patients with thyroid nodules, which according to ultrasonography (US) of the thyroid were classified as TR-4 category of thyroid nodules, TIRADS scale (4–6 points, suspected malignant thyroid changes). The examination included the following: questionnaire, ultrasound examination with fine-needle aspiration puncture biopsy, cytological examination, counting the thyroid hormone concentration, full blood count. The study was carried out at the premises of State Institution “Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine”. Results. Assessment of thyroid status of patients with thyroid nodules showed a significant correlation between the severity of thyroid malignancy and TSH levels (according to Kruskal – Wallis test, H = 7.30, p < 0.05), FT4 (H = 17.64, p < 0.001) and FT3 (H = 12.41, p < 0.01). Patients of Group I with benign thyroid process showed significant (p < 0.05) decrease in total hemoglobin along with significantly frequent (p < 0.05) microcytic anemia. According to the studies, Group II had a significant (p < 0.05) decrease in total platelet count and plateletcrit, as well as an increased average platelet volume and the percentage of large platelets compared to Group I. The blood values in malignant thyroid process (Group III) are characterized by increased levels of leukocytes and the proportion of eosinophils and basophils in the leukocyte formula compared to Group II (p < 0.05). Conclusions. The outcomes of comprehensive assessment of thyroid status and full blood count values in patients with thyroid nodules can be used in preoperative diagnosis as a differential prognostic tool to assess their malignant potential.https://ukroj.com/index.php/journal/article/view/72thyroid cancer, diagnosis, hormones, anemia, fine-needle aspiration.
spellingShingle М. Ю. Поліон
Н. О. Гладких
О. І. Залюбовська
П. О. Гриценко
Significance of changes in general clinical analysis of blood and thyroid status in people with neoplasm of the thyroid gland
Український радіологічний та онкологічний журнал
thyroid cancer, diagnosis, hormones, anemia, fine-needle aspiration.
title Significance of changes in general clinical analysis of blood and thyroid status in people with neoplasm of the thyroid gland
title_full Significance of changes in general clinical analysis of blood and thyroid status in people with neoplasm of the thyroid gland
title_fullStr Significance of changes in general clinical analysis of blood and thyroid status in people with neoplasm of the thyroid gland
title_full_unstemmed Significance of changes in general clinical analysis of blood and thyroid status in people with neoplasm of the thyroid gland
title_short Significance of changes in general clinical analysis of blood and thyroid status in people with neoplasm of the thyroid gland
title_sort significance of changes in general clinical analysis of blood and thyroid status in people with neoplasm of the thyroid gland
topic thyroid cancer, diagnosis, hormones, anemia, fine-needle aspiration.
url https://ukroj.com/index.php/journal/article/view/72
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