Immunohistochemical expression of Type IV Collagen and Autocrine Motility Factor Receptor in Odontogenic Tumours
Background: Autocrine motility factor receptor (AMFR) is a tumour motility stimulating protein secreted by tumour cells. The protein encoded by this gene is a glycosylated transmembrane protein and a receptor for autocrine motility factor. It has been known to play a role in progression of neopl...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4951/9405_CE(Ra)_F(Sh)_PF1(SNAK)_PFA(Sh)_PF2(PAG).pdf |
| Summary: | Background: Autocrine motility factor receptor (AMFR) is a
tumour motility stimulating protein secreted by tumour cells. The
protein encoded by this gene is a glycosylated transmembrane
protein and a receptor for autocrine motility factor. It has been
known to play a role in progression of neoplastic lesions.
Basement membranes are specialized extracellular matrices
that serve as structural barriers as well as substrates for cellular
interactions. The network of type IV collagen is thought to define
the scaffold integrating other components such as laminins and
perlecan into highly organized supramolecular architecture.
The aim of this study was to determine and evaluate the
immunohistochemical expression of Type IV Collagen and
Autocrine motility factor receptor in odontogenic lesions.
Materials and Methods: Immunohistochemical expression
of Type IV Collagen and Autocrine motility factor receptor
was evaluated in 31 odontogenic lesions, including unicystic
ameloblastoma, multicystic ameloblastoma, keratocystic
odontogenic tumour and ameloblastic carcinoma. Normal
follicular tissue formed the control.
Results: Maximum expression for Type IV Collagen was seen
in multicystic ameloblastoma and minimum expression in
keratocystic odontogenic tumour. The maximum expression
of AMFR was seen in ameloblastic carcinoma and minimum
expression in multicystic ameloblastoma.
Conclusion: The results of this study suggested an association
of loss of expression of type IV Collagen with progression of
lesion. AMFR expression was found to be associated with the
aggressive potential of tumours. |
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| ISSN: | 2249-782X 0973-709X |