Immunohistochemical expression of Type IV Collagen and Autocrine Motility Factor Receptor in Odontogenic Tumours
Background: Autocrine motility factor receptor (AMFR) is a tumour motility stimulating protein secreted by tumour cells. The protein encoded by this gene is a glycosylated transmembrane protein and a receptor for autocrine motility factor. It has been known to play a role in progression of neopl...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2014-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/4951/9405_CE(Ra)_F(Sh)_PF1(SNAK)_PFA(Sh)_PF2(PAG).pdf |
| _version_ | 1818840662156509184 |
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| author | Harshaminder Kaur Grewal Sneha Sethi |
| author_facet | Harshaminder Kaur Grewal Sneha Sethi |
| author_sort | Harshaminder Kaur Grewal |
| collection | DOAJ |
| description | Background: Autocrine motility factor receptor (AMFR) is a
tumour motility stimulating protein secreted by tumour cells. The
protein encoded by this gene is a glycosylated transmembrane
protein and a receptor for autocrine motility factor. It has been
known to play a role in progression of neoplastic lesions.
Basement membranes are specialized extracellular matrices
that serve as structural barriers as well as substrates for cellular
interactions. The network of type IV collagen is thought to define
the scaffold integrating other components such as laminins and
perlecan into highly organized supramolecular architecture.
The aim of this study was to determine and evaluate the
immunohistochemical expression of Type IV Collagen and
Autocrine motility factor receptor in odontogenic lesions.
Materials and Methods: Immunohistochemical expression
of Type IV Collagen and Autocrine motility factor receptor
was evaluated in 31 odontogenic lesions, including unicystic
ameloblastoma, multicystic ameloblastoma, keratocystic
odontogenic tumour and ameloblastic carcinoma. Normal
follicular tissue formed the control.
Results: Maximum expression for Type IV Collagen was seen
in multicystic ameloblastoma and minimum expression in
keratocystic odontogenic tumour. The maximum expression
of AMFR was seen in ameloblastic carcinoma and minimum
expression in multicystic ameloblastoma.
Conclusion: The results of this study suggested an association
of loss of expression of type IV Collagen with progression of
lesion. AMFR expression was found to be associated with the
aggressive potential of tumours. |
| first_indexed | 2024-12-19T04:13:45Z |
| format | Article |
| id | doaj.art-fc92f06362334959a9a8b890eab5fda9 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-19T04:13:45Z |
| publishDate | 2014-10-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-fc92f06362334959a9a8b890eab5fda92022-12-21T20:36:22ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-10-01810ZC17ZC2110.7860/JCDR/2014/9405.4951Immunohistochemical expression of Type IV Collagen and Autocrine Motility Factor Receptor in Odontogenic TumoursHarshaminder Kaur Grewal0Sneha Sethi1Professor and Head of Department, Department of Oral Pathology, Seema Dental College and Hospital, Rishikesh, India.Post-Graduate Student, Department of Oral and Maxillofacial Pathology, Maharishi Markandeshwar College of Dental Science and Research, Mullana, Ambala, India.Background: Autocrine motility factor receptor (AMFR) is a tumour motility stimulating protein secreted by tumour cells. The protein encoded by this gene is a glycosylated transmembrane protein and a receptor for autocrine motility factor. It has been known to play a role in progression of neoplastic lesions. Basement membranes are specialized extracellular matrices that serve as structural barriers as well as substrates for cellular interactions. The network of type IV collagen is thought to define the scaffold integrating other components such as laminins and perlecan into highly organized supramolecular architecture. The aim of this study was to determine and evaluate the immunohistochemical expression of Type IV Collagen and Autocrine motility factor receptor in odontogenic lesions. Materials and Methods: Immunohistochemical expression of Type IV Collagen and Autocrine motility factor receptor was evaluated in 31 odontogenic lesions, including unicystic ameloblastoma, multicystic ameloblastoma, keratocystic odontogenic tumour and ameloblastic carcinoma. Normal follicular tissue formed the control. Results: Maximum expression for Type IV Collagen was seen in multicystic ameloblastoma and minimum expression in keratocystic odontogenic tumour. The maximum expression of AMFR was seen in ameloblastic carcinoma and minimum expression in multicystic ameloblastoma. Conclusion: The results of this study suggested an association of loss of expression of type IV Collagen with progression of lesion. AMFR expression was found to be associated with the aggressive potential of tumours.https://jcdr.net/articles/PDF/4951/9405_CE(Ra)_F(Sh)_PF1(SNAK)_PFA(Sh)_PF2(PAG).pdfameloblastomaamfrkeratocystic odontogenic tumourprogression of odontogenic lesionstype iv collagen |
| spellingShingle | Harshaminder Kaur Grewal Sneha Sethi Immunohistochemical expression of Type IV Collagen and Autocrine Motility Factor Receptor in Odontogenic Tumours Journal of Clinical and Diagnostic Research ameloblastoma amfr keratocystic odontogenic tumour progression of odontogenic lesions type iv collagen |
| title | Immunohistochemical expression of Type IV Collagen and Autocrine Motility Factor Receptor in Odontogenic Tumours |
| title_full | Immunohistochemical expression of Type IV Collagen and Autocrine Motility Factor Receptor in Odontogenic Tumours |
| title_fullStr | Immunohistochemical expression of Type IV Collagen and Autocrine Motility Factor Receptor in Odontogenic Tumours |
| title_full_unstemmed | Immunohistochemical expression of Type IV Collagen and Autocrine Motility Factor Receptor in Odontogenic Tumours |
| title_short | Immunohistochemical expression of Type IV Collagen and Autocrine Motility Factor Receptor in Odontogenic Tumours |
| title_sort | immunohistochemical expression of type iv collagen and autocrine motility factor receptor in odontogenic tumours |
| topic | ameloblastoma amfr keratocystic odontogenic tumour progression of odontogenic lesions type iv collagen |
| url | https://jcdr.net/articles/PDF/4951/9405_CE(Ra)_F(Sh)_PF1(SNAK)_PFA(Sh)_PF2(PAG).pdf |
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