Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors

Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors

N-Methyl-D-aspartate receptors (NMDARs) in the brain are influenced by psychoactive drugs such as 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one (ketamine) and its analog 2-(ethylamino)-2-(3-methoxyphenyl)-cyclohexanone (methoxetamine). The recreational methoxetamine use can cause several toxici...

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Bibliographic Details
Main Authors:	Tomohiko Irie, Yuta Yanase, Yosuke Demizu, Makoto Usami, Ruri Kikura-Hanajiri
Format:	Article
Language:	English
Published:	Elsevier 2022-12-01
Series:	Journal of Pharmacological Sciences
Subjects:	N-Methyl-D-aspartate receptors methoxetamine deoxymethoxetamine methoxisopropamine methoxetamine metabolites
Online Access:	http://www.sciencedirect.com/science/article/pii/S134786132200072X

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