Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles
Transition metal-catalyzed C−H cyclization for medium-ring synthesis has been limited to reactive C−H bonds, the activation of unreactive C−H bonds still remains a challenge. Here the authors show the direct construction of 7-membered rings via Ni−Al co-catalyzed unreactive C−H cyclization of benzoi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23371-x |
| _version_ | 1818432584467611648 |
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| author | Jiang-Fei Li Wei-Wei Xu Rong-Hua Wang Yue Li Ge Yin Mengchun Ye |
| author_facet | Jiang-Fei Li Wei-Wei Xu Rong-Hua Wang Yue Li Ge Yin Mengchun Ye |
| author_sort | Jiang-Fei Li |
| collection | DOAJ |
| description | Transition metal-catalyzed C−H cyclization for medium-ring synthesis has been limited to reactive C−H bonds, the activation of unreactive C−H bonds still remains a challenge. Here the authors show the direct construction of 7-membered rings via Ni−Al co-catalyzed unreactive C−H cyclization of benzoimidazoles with alkenes, providing a series of tricyclic imidazoles. |
| first_indexed | 2024-12-14T16:07:31Z |
| format | Article |
| id | doaj.art-fc9481d72a2f432a9bd1db3333814250 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T16:07:31Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fc9481d72a2f432a9bd1db33338142502022-12-21T22:55:04ZengNature PortfolioNature Communications2041-17232021-05-011211910.1038/s41467-021-23371-xConstruction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazolesJiang-Fei Li0Wei-Wei Xu1Rong-Hua Wang2Yue Li3Ge Yin4Mengchun Ye5State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityTransition metal-catalyzed C−H cyclization for medium-ring synthesis has been limited to reactive C−H bonds, the activation of unreactive C−H bonds still remains a challenge. Here the authors show the direct construction of 7-membered rings via Ni−Al co-catalyzed unreactive C−H cyclization of benzoimidazoles with alkenes, providing a series of tricyclic imidazoles.https://doi.org/10.1038/s41467-021-23371-x |
| spellingShingle | Jiang-Fei Li Wei-Wei Xu Rong-Hua Wang Yue Li Ge Yin Mengchun Ye Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles Nature Communications |
| title | Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles |
| title_full | Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles |
| title_fullStr | Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles |
| title_full_unstemmed | Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles |
| title_short | Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles |
| title_sort | construction 7 membered ring via ni al bimetal enabled c h cyclization for synthesis of tricyclic imidazoles |
| url | https://doi.org/10.1038/s41467-021-23371-x |
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