Artichoke (Cynara scolymus L.) water extract alleviates palmitate-induced insulin resistance in HepG2 hepatocytes via the activation of IRS1/PI3K/AKT/FoxO1 and GSK-3β signaling pathway

Artichoke (Cynara scolymus L.) water extract alleviates palmitate-induced insulin resistance in HepG2 hepatocytes via the activation of IRS1/PI3K/AKT/FoxO1 and GSK-3β signaling pathway

Abstract Background Artichoke (Cynara scolymus L.) is a typical element of a traditional Mediterranean diet and has potential health advantages for insulin resistance (IR) and type 2 diabetes mellitus (T2DM). This study aims to evaluate the effect and underlying mechanism of artichoke water extract...

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Bibliographic Details
Main Authors: Aihua Deng, Yun Wang, Kerui Huang, Peng Xie, Ping Mo, Fengying Liu, Jun Chen, Kaiyi Chen, Bing Xiao
Format: Article
Language:English
Published: BMC 2023-12-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Artichoke
Insulin resistance
HepG2 cells
Gluconeogenesis
Glycogen synthesis
Online Access:https://doi.org/10.1186/s12906-023-04275-3

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