Complement downregulation promotes an inflammatory signature that renders colorectal cancer susceptible to immunotherapy

Background and aims The role of inflammatory immune responses in colorectal cancer (CRC) development and response to therapy is a matter of intense debate. While inflammation is a known driver of CRC, inflammatory immune infiltrates are a positive prognostic factor in CRC and predispose to response...

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Bibliographic Details
Main Authors: Enric Domingo, Sahar El Aidy, Gary Hardiman, Carsten Krieg, Lukas M Weber, Bruno Fosso, Marinella Marzano, Monica M Olcina, Khalil Mallah, Mark D Robinson, Silvia Guglietta
Format: Article
Language:English
Published: BMJ Publishing Group 2022-09-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/10/9/e004717.full